Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PrlF(antitoxin)
Location 2216371..2216935 Replicon chromosome
Accession NZ_CP039634
Organism Azospirillum sp. TSH100

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E6C72_RS10465 Protein ID WP_109443614.1
Coordinates 2216573..2216935 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E6C72_RS10460 Protein ID WP_109443615.1
Coordinates 2216371..2216586 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6C72_RS10435 2211677..2212558 - 882 WP_109443620.1 ATP-binding protein -
E6C72_RS10440 2212784..2213209 + 426 WP_109443619.1 preprotein translocase subunit YajC -
E6C72_RS10445 2213335..2214933 + 1599 WP_109443618.1 protein translocase subunit SecD -
E6C72_RS10450 2214945..2215901 + 957 WP_109443617.1 protein translocase subunit SecF -
E6C72_RS10455 2215932..2216309 + 378 WP_109443616.1 Mth938-like domain-containing protein -
E6C72_RS10460 2216371..2216586 + 216 WP_109443615.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
E6C72_RS10465 2216573..2216935 + 363 WP_109443614.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E6C72_RS10470 2217000..2217593 - 594 WP_109443613.1 superoxide dismutase -
E6C72_RS10475 2217599..2218987 - 1389 WP_109443612.1 hydroxysqualene dehydroxylase HpnE -
E6C72_RS10480 2218987..2219889 - 903 WP_109443611.1 presqualene diphosphate synthase HpnD -
E6C72_RS10485 2219960..2220832 - 873 WP_109443610.1 squalene/phytoene synthase family protein -
E6C72_RS10490 2220956..2221810 + 855 WP_109443609.1 squalene/phytoene synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-102)

Antitoxin

PrlF antitoxin

(4-52)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13166.09 Da        Isoelectric Point: 7.3198

>T124181 WP_109443614.1 NZ_CP039634:2216573-2216935 [Azospirillum sp. TSH100]
MPTFETWNVVKVPFPYADRPVRQRRPALVIAADDLQASHSLIWVLMITSADNRSWPSDVPVNDLGTAGLPSPSVVRTAKV
AVIDARDAELLGTLSVSDRRTVSLQVGHHLEEMLKVGRNA

Download         Length: 363 bp

>T124181 NZ_CP039634:2216573-2216935 [Azospirillum sp. TSH100]
ATGCCGACCTTTGAAACCTGGAATGTCGTAAAGGTTCCGTTCCCTTATGCCGATCGCCCGGTTCGCCAACGTCGGCCGGC
GTTGGTCATTGCCGCAGACGATCTGCAAGCAAGCCACAGCCTGATCTGGGTATTGATGATCACCAGCGCCGATAACCGGA
GCTGGCCGTCCGACGTGCCTGTTAACGATCTCGGTACTGCAGGGTTGCCCTCTCCGTCCGTCGTACGGACGGCGAAGGTC
GCCGTGATCGATGCGCGTGACGCTGAACTGCTTGGTACCCTTTCGGTCAGCGACCGCCGAACGGTCAGTCTGCAGGTTGG
TCACCATCTTGAAGAGATGCTGAAGGTCGGACGAAACGCATAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7939.91 Da        Isoelectric Point: 4.4865

>AT124181 WP_109443615.1 NZ_CP039634:2216371-2216586 [Azospirillum sp. TSH100]
MITSKLTSKAQTTIPQPVRAALGLHEGDEIAYRIEDGRVILTRAAPAFVDDPFRCFTEWDSEADRQAYADL

Download         Length: 216 bp

>AT124181 NZ_CP039634:2216371-2216586 [Azospirillum sp. TSH100]
ATGATCACCAGCAAGCTGACCAGCAAGGCCCAGACAACCATTCCACAGCCGGTACGGGCAGCCCTGGGCCTGCATGAGGG
CGACGAGATCGCCTACAGGATCGAGGACGGCCGCGTTATCCTGACCCGCGCCGCTCCGGCTTTTGTCGACGATCCCTTTC
GCTGCTTTACGGAATGGGATAGTGAAGCGGATCGGCAGGCCTATGCCGACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References