Detailed information of TA system TA124179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 5676689..5677305
• Replicon: chromosome
• Accession: NZ_CP039631
• Organism: Pseudomonas veronii strain Pvy

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E4167_RS25700
• Protein ID: WP_155678533.1
• Coordinates: 5676689..5676943 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A2N7YF18
• Locus tag: E4167_RS25705
• Protein ID: WP_046488352.1
• Coordinates: 5676940..5677305 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4167_RS25695	5675278..5676453	-	1176	WP_155678532.1	ISL3 family transposase	-
E4167_RS25700	5676689..5676943	+	255	WP_155678533.1	type II toxin-antitoxin system HicA family toxin	Toxin
E4167_RS25705	5676940..5677305	+	366	WP_046488352.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E4167_RS25710	5677306..5678481	-	1176	WP_155678534.1	MFS transporter	-
E4167_RS25715	5678522..5679881	-	1360	Protein_5007	MATE family efflux transporter	-
E4167_RS25720	5679907..5680479	-	573	WP_141123520.1	DUF2239 family protein	-
E4167_RS25725	5680576..5681619	-	1044	WP_155678535.1	aliphatic amidase	-
E4167_RS25730	5681635..5681982	-	348	WP_046383751.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9625.22 Da
• Isoelectric Point: 10.2601

>T124179 WP_155678533.1 NZ_CP039631:5676689-5676943 [Pseudomonas veronii]
VSKNEKLLAKLLNEQMAFTWPETVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKKSG
ELIQ

Nucleotide

• Length: 255 bp

>T124179 NZ_CP039631:5676689-5676943 [Pseudomonas veronii]
GTGTCCAAAAATGAAAAGCTGCTCGCCAAACTGCTCAACGAGCAAATGGCATTTACCTGGCCCGAAACCGTCACGCTGCT
GCGTCGTCTTGGCTACACACAGATTGAAGGGGCGGGAAGCCGCGTCAAGTTCGACATCGGCGACCCCAGTGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAATGAACTGAAACACTACATTCGGCGCCAGATCATCGAACAATTGAAGAAATCAGGA
GAACTGATTCAGTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13164.13 Da
• Isoelectric Point: 6.9478

>AT124179 WP_046488352.1 NZ_CP039631:5676940-5677305 [Pseudomonas veronii]
VNNQLKHQGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCLALGQTPEKPCKGSFNVRVGH
DLHLAAALEATRKKVTLNDLTRQALSEFLLHHCAKPTPAIG

Nucleotide

• Length: 366 bp

>AT124179 NZ_CP039631:5676940-5677305 [Pseudomonas veronii]
GTGAACAACCAATTGAAACACCAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTGTTCGGCAAGAT
CCTGTTTATCAAGGCGCTGGTGAGCTACGAAGGGAAAACCGTCGCCGAACTGGATGCGGCATTTCGTGAGGCGGTGGACG
ACTATCTCGCCACCTGCCTGGCCCTTGGGCAAACACCGGAAAAACCATGCAAGGGTTCATTCAACGTGCGGGTCGGGCAT
GACCTTCATCTGGCCGCAGCCCTGGAAGCTACACGCAAGAAGGTGACCCTGAACGACCTGACACGCCAAGCGCTGAGTGA
GTTCCTGCTACATCACTGCGCCAAACCCACCCCCGCGATCGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2N7YF18