Detailed information of TA system TA124178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1463411..1464450
• Replicon: chromosome
• Accession: NZ_CP039631
• Organism: Pseudomonas veronii strain Pvy

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: A0A2N7YN67
• Locus tag: E4167_RS06555
• Protein ID: WP_046488818.1
• Coordinates: 1463875..1464450 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A2N7YN66
• Locus tag: E4167_RS06550
• Protein ID: WP_046488815.1
• Coordinates: 1463411..1463878 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4167_RS06530	1458484..1459692	-	1209	WP_046488795.1	response regulator	-
E4167_RS06535	1459831..1461108	-	1278	WP_017848615.1	4-aminobutyrate--2-oxoglutarate transaminase	-
E4167_RS06540	1461290..1462732	-	1443	WP_017848616.1	NADP-dependent succinate-semialdehyde dehydrogenase	-
E4167_RS06550	1463411..1463878	+	468	WP_046488815.1	helix-turn-helix domain-containing protein	Antitoxin
E4167_RS06555	1463875..1464450	+	576	WP_046488818.1	PIN domain-containing protein	Toxin
E4167_RS06560	1464866..1465960	-	1095	WP_141123065.1	2,3-butanediol dehydrogenase	-
E4167_RS06565	1466348..1466938	-	591	WP_155677444.1	hypothetical protein	-
E4167_RS06570	1466935..1467510	-	576	WP_155677445.1	RNA polymerase sigma factor	-
E4167_RS06575	1467549..1469174	-	1626	WP_155677446.1	VWA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-115)

Antitoxin

• SinI-like, DNA-binding domain (84-131)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21807.98 Da
• Isoelectric Point: 5.0798

>T124178 WP_046488818.1 NZ_CP039631:1463875-1464450 [Pseudomonas veronii]
MRHSPFTAFYDANVLYPAPLRDYLMHLALTGVYRARWSALIHEEWKRNLLINRPELTREQLDRTSSLMDKAVPDGIVTEY
EPLIEGLTLPDADDRHVLAAAIKCNASVIVTFNLKDFPKSALDAFDIEPLHPDDFIADLWDLDQAAVLEAAQRQRASLKN
PPHSAREYLDKLLQQKLPETVKLLSGFEFLI

Nucleotide

• Length: 576 bp

>T124178 NZ_CP039631:1463875-1464450 [Pseudomonas veronii]
ATGAGGCATTCACCTTTCACAGCCTTCTACGACGCGAATGTTCTCTACCCTGCACCACTGCGTGACTACTTGATGCATCT
AGCCTTGACCGGCGTGTACCGCGCACGCTGGTCAGCTCTGATTCATGAAGAATGGAAGCGCAATCTACTGATCAACCGTC
CAGAGCTTACACGTGAGCAATTGGACCGAACGTCCTCGCTGATGGATAAAGCCGTTCCGGATGGTATTGTCACTGAATAC
GAGCCTCTTATAGAGGGACTGACTCTACCGGACGCTGACGACCGCCATGTGCTGGCAGCAGCTATCAAATGTAACGCCTC
GGTTATCGTGACTTTTAACCTTAAGGATTTCCCAAAGAGCGCTCTCGACGCGTTCGATATAGAGCCATTACACCCTGACG
ACTTTATTGCCGACCTATGGGATCTAGATCAAGCAGCTGTTTTGGAAGCAGCGCAAAGGCAGCGTGCATCCCTGAAAAAC
CCACCGCATAGCGCACGCGAGTATCTAGATAAGCTACTACAGCAGAAGCTACCCGAAACCGTAAAATTGCTGTCCGGTTT
TGAGTTCCTGATTTGA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17231.72 Da
• Isoelectric Point: 6.0048

>AT124178 WP_046488815.1 NZ_CP039631:1463411-1463878 [Pseudomonas veronii]
MTTANLARTILPDEKEIAAAVASSRQLAAFLTTKFETQRIELVDETQHREVVELPTFALRLLGEILSELALGNAVKVVPI
HAELTTQEGADMLNVSRPHLVKLLDNGALPHTKTGRHRRIKFADLMTYKEQRDQASRNAMDELAAQAQELGMGYE

Nucleotide

• Length: 468 bp

>AT124178 NZ_CP039631:1463411-1463878 [Pseudomonas veronii]
ATGACCACCGCCAACCTCGCTCGCACCATTCTTCCCGATGAGAAGGAAATCGCTGCGGCCGTGGCGTCAAGCCGTCAGTT
GGCCGCCTTCCTCACAACAAAATTTGAGACACAACGCATTGAGTTGGTTGACGAAACGCAACACCGCGAAGTCGTCGAAC
TTCCTACTTTCGCCCTCCGTTTACTCGGCGAAATTTTAAGCGAACTCGCGCTGGGTAACGCCGTCAAGGTCGTGCCGATT
CATGCGGAATTAACGACCCAAGAAGGGGCAGACATGCTCAATGTTTCGCGGCCTCACCTGGTGAAACTACTGGATAACGG
CGCATTGCCCCACACCAAAACCGGGAGACATCGTAGGATCAAGTTCGCTGATCTAATGACCTACAAGGAGCAACGCGACC
AGGCAAGCCGTAATGCCATGGATGAGCTAGCTGCACAAGCCCAAGAATTAGGGATGGGGTATGAATGA

Structures

Toxin

• AlphaFold DB: A0A2N7YN67

Antitoxin

• AlphaFold DB: A0A2N7YN66