Detailed information of TA system TA124176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 29708..30306
• Replicon: plasmid pAeca2
• Accession: NZ_CP039628
• Organism: Aeromonas caviae strain T25-39

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: C1C91_RS23190
• Protein ID: WP_258057479.1
• Coordinates: 29708..30055 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: C1C91_RS23195
• Protein ID: WP_258057480.1
• Coordinates: 30055..30306 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1C91_RS23170 (C1C91_23405)	28027..28440	-	414	WP_258057475.1	hypothetical protein	-
C1C91_RS23175 (C1C91_23410)	28484..28966	-	483	WP_258057476.1	hypothetical protein	-
C1C91_RS23180 (C1C91_23415)	29153..29374	-	222	WP_258057477.1	hypothetical protein	-
C1C91_RS23185 (C1C91_23420)	29390..29695	-	306	WP_258057478.1	hypothetical protein	-
C1C91_RS23190 (C1C91_23425)	29708..30055	-	348	WP_258057479.1	type II toxin-antitoxin system ChpB family toxin	Toxin
C1C91_RS23195 (C1C91_23430)	30055..30306	-	252	WP_258057480.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C1C91_RS23200	30372..30593	-	222	WP_258057481.1	hypothetical protein	-
C1C91_RS23205 (C1C91_23440)	30937..31620	-	684	WP_258057482.1	restriction endonuclease	-
C1C91_RS23210 (C1C91_23445)	31631..33460	-	1830	WP_258057483.1	conjugal transfer protein TraN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	tet(E) / sul1 / aadA16 / catB3 / dfrB4	-	1..103136	103136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-113)

Antitoxin

• SpoVT-AbrB domain (8-50)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 11990.98 Da
• Isoelectric Point: 8.5139

>T124176 WP_258057479.1 NZ_CP039628:c30055-29708 [Aeromonas caviae]
MAAFDRGDIVKACLNPVAGHEMQGERRPCLVLSPRAYNKLGLTIVVPITQGGDYSRFQGFAVTLMGSGTETQGVALVNGI
KSLDLAARGAKKVETAPPAIVDEVLAKLAAVLNIG

Nucleotide

• Length: 348 bp

>T124176 NZ_CP039628:c30055-29708 [Aeromonas caviae]
ATGGCGGCATTTGATCGGGGTGACATTGTGAAAGCGTGCCTGAATCCAGTAGCAGGCCATGAAATGCAAGGTGAGCGCCG
CCCCTGCTTGGTGCTGTCTCCCAGGGCGTACAACAAGTTGGGGTTAACCATCGTCGTACCGATTACCCAAGGCGGCGATT
ATTCCCGTTTTCAAGGGTTCGCGGTAACGCTGATGGGATCCGGCACCGAGACACAAGGGGTTGCCCTGGTGAACGGGATC
AAGTCATTAGATCTGGCTGCCCGTGGCGCTAAGAAGGTCGAAACTGCGCCGCCCGCGATAGTTGACGAGGTGCTGGCAAA
GCTGGCCGCCGTCTTGAACATTGGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8743.13 Da
• Isoelectric Point: 4.9222

>AT124176 WP_258057480.1 NZ_CP039628:c30306-30055 [Aeromonas caviae]
MKTALRAIGNSKGAVIPASLLRELNLNVGDQLNARAVDGALILTPSRKPKYTLAELLAQCDASAPMPVGLADWDSMEPVG
NEI

Nucleotide

• Length: 252 bp

>AT124176 NZ_CP039628:c30306-30055 [Aeromonas caviae]
ATGAAAACTGCACTACGTGCCATTGGCAATTCTAAGGGGGCGGTAATCCCCGCCTCCCTGCTACGCGAGCTGAATCTGAA
CGTGGGCGACCAGCTGAATGCCCGCGCAGTAGATGGGGCGCTGATCCTGACTCCGAGCCGTAAGCCCAAATACACATTGG
CTGAGTTGTTGGCCCAGTGTGATGCGTCTGCTCCGATGCCTGTAGGGTTGGCCGACTGGGATAGCATGGAGCCGGTGGGG
AATGAGATCTGA