Detailed information of TA system TA124174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 18069..18712
• Replicon: plasmid PNCS014868 strain 14[5]12:i:-
• Accession: NZ_CP039605
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014868

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: Q84A06
• Locus tag: E5O12_RS24295
• Protein ID: WP_000754566.1
• Coordinates: 18296..18712 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: Q84A07
• Locus tag: E5O12_RS24290
• Protein ID: WP_001261276.1
• Coordinates: 18069..18299 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O12_RS24255	13188..13457	+	270	WP_000339857.1	hypothetical protein	-
E5O12_RS24260	13634..14500	-	867	WP_004118283.1	replication initiation protein	-
E5O12_RS24500	15030..15134	+	105	WP_032409716.1	hypothetical protein	-
E5O12_RS24265	15263..15520	+	258	WP_000764642.1	hypothetical protein	-
E5O12_RS24270	15578..16354	-	777	WP_000015958.1	site-specific integrase	-
E5O12_RS24275	16351..17094	-	744	WP_000129823.1	hypothetical protein	-
E5O12_RS24280	17145..17495	-	351	WP_000493378.1	hypothetical protein	-
E5O12_RS24290	18069..18299	+	231	WP_001261276.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E5O12_RS24295	18296..18712	+	417	WP_000754566.1	type II toxin-antitoxin system VapC family toxin	Toxin
E5O12_RS24300	18916..19772	+	857	Protein_24	IS3-like element ISEc15 family transposase	-
E5O12_RS24310	20054..21130	+	1077	WP_000227969.1	IS110 family transposase	-
E5O12_RS24315	21501..21719	-	219	WP_004193160.1	hypothetical protein	-
E5O12_RS24320	21771..21854	+	84	Protein_27	SOS response-associated peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..38556	38556

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 17834.22 Da
• Isoelectric Point: 12.9398

>T124174 WP_000754566.1 NZ_CP039605:18296-18712 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 417 bp

>T124174 NZ_CP039605:18296-18712 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 9887.42 Da
• Isoelectric Point: 12.6808

>AT124174 WP_001261276.1 NZ_CP039605:18069-18299 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 231 bp

>AT124174 NZ_CP039605:18069-18299 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A387K1G3

Antitoxin

• AlphaFold DB: A0A387K023