Detailed information of TA system TA124173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 31445..31967
• Replicon: plasmid PNCS014867 strain 14[5]12:i:-
• Accession: NZ_CP039600
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014867

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D0QMR1
• Locus tag: E5O11_RS24435
• Protein ID: WP_000220561.1
• Coordinates: 31445..31726 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: E5O11_RS24440
• Protein ID: WP_000121743.1
• Coordinates: 31716..31967 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O11_RS24395	27290..28456	-	1167	WP_052909232.1	relaxase/mobilization nuclease domain-containing protein	-
E5O11_RS24400	28459..29004	-	546	WP_106777835.1	DNA distortion polypeptide 1	-
E5O11_RS24405	29330..29602	-	273	WP_000160399.1	hypothetical protein	-
E5O11_RS24410	29834..30013	-	180	WP_072104066.1	hypothetical protein	-
E5O11_RS24415	30056..30385	-	330	WP_000866648.1	hypothetical protein	-
E5O11_RS24420	30478..30693	-	216	WP_001180116.1	hypothetical protein	-
E5O11_RS24425	30683..30928	-	246	WP_052909233.1	hypothetical protein	-
E5O11_RS24430	30976..31299	-	324	WP_052909234.1	hypothetical protein	-
E5O11_RS24435	31445..31726	-	282	WP_000220561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5O11_RS24440	31716..31967	-	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
E5O11_RS24450	33201..34040	+	840	WP_001352874.1	replication initiation protein	-
E5O11_RS24455	34061..34903	+	843	WP_106777834.1	replication initiation protein	-
E5O11_RS24460	34907..35350	+	444	WP_052909236.1	hypothetical protein	-
E5O11_RS24465	35490..35846	+	357	WP_001546351.1	hypothetical protein	-
E5O11_RS24470	35843..36820	-	978	WP_052909237.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..38266	38266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T124173 WP_000220561.1 NZ_CP039600:c31726-31445 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T124173 NZ_CP039600:c31726-31445 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT124173 WP_000121743.1 NZ_CP039600:c31967-31716 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT124173 NZ_CP039600:c31967-31716 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A3S5I302

Antitoxin

• AlphaFold DB: A0A3S5I301