Detailed information of TA system TA124170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 50172..50697
• Replicon: plasmid p11-0500.1
• Accession: NZ_CP039592
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain PNCS014862

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: E5O05_RS24790
• Protein ID: WP_001159863.1
• Coordinates: 50392..50697 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: E5O05_RS24785
• Protein ID: WP_000813641.1
• Coordinates: 50172..50390 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O05_RS24755	45459..45840	+	382	Protein_50	NirD/YgiW/YdeI family stress tolerance protein	-
E5O05_RS24760	46117..46453	+	337	Protein_51	site-specific integrase	-
E5O05_RS24765	46712..47701	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
E5O05_RS24770	48195..48491	-	297	WP_001687482.1	hypothetical protein	-
E5O05_RS24780	48975..49496	-	522	WP_010999942.1	hypothetical protein	-
E5O05_RS24785	50172..50390	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
E5O05_RS24790	50392..50697	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
E5O05_RS24795	50699..50989	+	291	WP_001266176.1	hypothetical protein	-
E5O05_RS24800	50986..51507	+	522	WP_000198608.1	hypothetical protein	-
E5O05_RS24805	51542..52324	+	783	WP_000082169.1	site-specific integrase	-
E5O05_RS24810	52333..53046	+	714	Protein_60	EAL domain-containing protein	-
E5O05_RS24820	53050..53559	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
E5O05_RS24825	53553..54038	+	486	WP_000905606.1	membrane protein	-
E5O05_RS24830	54315..54602	-	288	WP_071530243.1	hypothetical protein	-
E5O05_RS24835	54758..55318	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93998	93998

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T124170 WP_001159863.1 NZ_CP039592:50392-50697 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T124170 NZ_CP039592:50392-50697 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT124170 WP_000813641.1 NZ_CP039592:50172-50390 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT124170 NZ_CP039592:50172-50390 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6