Detailed information of TA system TA124169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 22713..23341
• Replicon: plasmid p11-0500.1
• Accession: NZ_CP039592
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain PNCS014862

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E5O05_RS24615
• Protein ID: WP_000911322.1
• Coordinates: 22713..23111 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q93GL5
• Locus tag: E5O05_RS24620
• Protein ID: WP_001526804.1
• Coordinates: 23111..23341 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O05_RS24600	18787..19281	+	495	WP_010999946.1	entry exclusion protein	-
E5O05_RS24605	19317..20048	+	732	WP_022743186.1	complement resistance protein TraT	-
E5O05_RS24610	20425..22704	+	2280	WP_110029902.1	type IV conjugative transfer system coupling protein TraD	-
E5O05_RS24615	22713..23111	-	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
E5O05_RS24620	23111..23341	-	231	WP_001526804.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93998	93998

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 19592.50 Da
• Isoelectric Point: 5.5500

>T124169 WP_000911322.1 NZ_CP039592:c23111-22713 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 399 bp

>T124169 NZ_CP039592:c23111-22713 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT124169 WP_001526804.1 NZ_CP039592:c23341-23111 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT124169 NZ_CP039592:c23341-23111 [Salmonella enterica subsp. enterica serovar Typhimurium]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A4P7Y1S4