Detailed information of TA system TA124168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/Xre(antitoxin)
• Location: 21565..22066
• Replicon: plasmid PNCS014859 strain 14[5]12:i:-
• Accession: NZ_CP039587
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014859

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: A0A6X6XTU7
• Locus tag: E5O02_RS24480
• Protein ID: WP_000702245.1
• Coordinates: 21806..22066 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: E5O02_RS24475
• Protein ID: WP_001132407.1
• Coordinates: 21565..21816 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O02_RS24420	16901..17632	+	732	WP_021575838.1	hypothetical protein	-
E5O02_RS24425	17652..18104	+	453	WP_052975314.1	hypothetical protein	-
E5O02_RS24430	18106..18300	+	195	WP_000224731.1	hypothetical protein	-
E5O02_RS24435	18302..18511	+	210	WP_000951714.1	hypothetical protein	-
E5O02_RS24440	18508..18834	+	327	WP_000206697.1	hypothetical protein	-
E5O02_RS24445	18965..19402	-	438	WP_000466318.1	type II toxin-antitoxin system HicB family antitoxin	-
E5O02_RS24450	19427..19609	-	183	WP_000833470.1	type II toxin-antitoxin system HicA family toxin	-
E5O02_RS24455	20167..20349	+	183	WP_024135751.1	hypothetical protein	-
E5O02_RS24460	20737..21015	-	279	WP_025380728.1	hypothetical protein	-
E5O02_RS24475	21565..21816	-	252	WP_001132407.1	transcriptional regulator	Antitoxin
E5O02_RS24480	21806..22066	-	261	WP_000702245.1	hypothetical protein	Toxin
E5O02_RS24485	22118..22342	-	225	WP_000814384.1	hypothetical protein	-
E5O02_RS24490	22440..22649	-	210	WP_000866037.1	hypothetical protein	-
E5O02_RS24495	22690..23013	-	324	WP_000432876.1	hypothetical protein	-
E5O02_RS24505	23595..23924	-	330	WP_000855120.1	hypothetical protein	-
E5O02_RS24515	24521..25186	+	666	WP_000532148.1	P-loop NTPase	-
E5O02_RS24520	25374..25544	+	171	WP_000186151.1	hypothetical protein	-
E5O02_RS24525	25562..26134	-	573	WP_115209233.1	hypothetical protein	-
E5O02_RS24530	26312..26527	-	216	WP_000893075.1	FlmC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..59143	59143

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 12822.38 Da
• Isoelectric Point: 5.5500

>T124168 WP_000702245.1 NZ_CP039587:c22066-21806 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFF

Nucleotide

• Length: 261 bp

>T124168 NZ_CP039587:c22066-21806 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 12380.85 Da
• Isoelectric Point: 5.5500

>AT124168 WP_001132407.1 NZ_CP039587:c21816-21565 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Nucleotide

• Length: 252 bp

>AT124168 NZ_CP039587:c21816-21565 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Structures

Toxin

• AlphaFold DB: A0A6X6XTU7