Detailed information of TA system TA124166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 22657..23285
• Replicon: plasmid PNCS014859 strain 14[5]12:i:-
• Accession: NZ_CP039586
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014859

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E5O02_RS23865
• Protein ID: WP_000911322.1
• Coordinates: 22657..23055 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q93GL5
• Locus tag: E5O02_RS23870
• Protein ID: WP_001526804.1
• Coordinates: 23055..23285 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O02_RS23850	18794..19288	+	495	WP_010999946.1	entry exclusion protein	-
E5O02_RS23855	19324..20055	+	732	WP_000782438.1	complement resistance protein TraT	-
E5O02_RS23860	20432..22648	+	2217	WP_136571654.1	type IV conjugative transfer system coupling protein TraD	-
E5O02_RS23865	22657..23055	-	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
E5O02_RS23870	23055..23285	-	231	WP_001526804.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93927	93927

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-81)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 19592.50 Da
• Isoelectric Point: 5.5500

>T124166 WP_000911322.1 NZ_CP039586:c23055-22657 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 399 bp

>T124166 NZ_CP039586:c23055-22657 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT124166 WP_001526804.1 NZ_CP039586:c23285-23055 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT124166 NZ_CP039586:c23285-23055 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Structures

Antitoxin

• AlphaFold DB: A0A4P7Y1S4