Detailed information of TA system TA124162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 8108..8736
• Replicon: plasmid PNCS014857 strain 14[5]12:i:-
• Accession: NZ_CP039580
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS014857

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E5N99_RS24340
• Protein ID: WP_000911322.1
• Coordinates: 8108..8506 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q93GL5
• Locus tag: E5N99_RS24345
• Protein ID: WP_001526804.1
• Coordinates: 8506..8736 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5N99_RS24325	4218..4712	+	495	WP_010999946.1	entry exclusion protein	-
E5N99_RS24330	4748..5479	+	732	WP_022743186.1	complement resistance protein TraT	-
E5N99_RS24335	5856..8099	+	2244	WP_031608981.1	type IV conjugative transfer system coupling protein TraD	-
E5N99_RS24340	8108..8506	-	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
E5N99_RS24345	8506..8736	-	231	WP_001526804.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..125502	125502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (20-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (84-135)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 19592.50 Da
• Isoelectric Point: 5.5500

>T124162 WP_000911322.1 NZ_CP039580:c8506-8108 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 399 bp

>T124162 NZ_CP039580:c8506-8108 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 11350.61 Da
• Isoelectric Point: 5.5500

>AT124162 WP_001526804.1 NZ_CP039580:c8736-8506 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 231 bp

>AT124162 NZ_CP039580:c8736-8506 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
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Structures

Antitoxin

• AlphaFold DB: A0A4P7Y1S4