Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3099119..3099705 Replicon chromosome
Accession NZ_CP039546
Organism Methylorubrum populi strain YC-XJ1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E8E01_RS14540 Protein ID WP_141951866.1
Coordinates 3099403..3099705 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E8E01_RS14535 Protein ID WP_012455043.1
Coordinates 3099119..3099406 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8E01_RS14515 3095247..3095834 + 588 WP_186442271.1 hypothetical protein -
E8E01_RS14520 3095969..3097240 - 1272 WP_141951863.1 tyrosine--tRNA ligase -
E8E01_RS14525 3097379..3098512 + 1134 WP_141951864.1 anhydro-N-acetylmuramic acid kinase -
E8E01_RS14530 3098509..3099114 + 606 WP_141951865.1 DUF3578 domain-containing protein -
E8E01_RS14535 3099119..3099406 - 288 WP_012455043.1 putative addiction module antidote protein Antitoxin
E8E01_RS14540 3099403..3099705 - 303 WP_141951866.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E8E01_RS14545 3099838..3100938 + 1101 WP_141951867.1 chorismate synthase -
E8E01_RS14550 3100974..3102050 + 1077 WP_141951868.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
E8E01_RS14555 3102149..3102382 + 234 WP_141951869.1 hypothetical protein -
E8E01_RS14560 3102407..3103336 - 930 WP_141954883.1 histone deacetylase family protein -
E8E01_RS14570 3103989..3104459 + 471 WP_141951870.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-84)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11184.98 Da        Isoelectric Point: 10.4449

>T124102 WP_141951866.1 NZ_CP039546:c3099705-3099403 [Methylorubrum populi]
MPEIIRTRVFADWLRGLRDDRAKARIALRIDRLALGHEGDSKPVGGGVSELRIDYGPGYRIYFKYRDGTLVILLCGGDKS
SQKRDIARALSLAATLKEKP

Download         Length: 303 bp

>T124102 NZ_CP039546:c3099705-3099403 [Methylorubrum populi]
ATGCCGGAGATTATCCGAACCCGCGTGTTCGCGGACTGGCTCCGAGGACTTCGAGACGATCGTGCGAAGGCACGGATCGC
GTTACGGATCGACCGCCTTGCACTTGGCCATGAAGGTGATTCGAAGCCTGTCGGCGGAGGCGTCAGCGAACTGAGGATCG
ATTACGGGCCGGGTTACCGGATCTACTTCAAGTACCGCGACGGAACGCTCGTCATCCTTCTTTGTGGAGGGGACAAGTCC
AGCCAGAAGCGCGACATCGCCCGTGCGCTCTCCCTCGCAGCGACGCTGAAAGAAAAGCCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10195.38 Da        Isoelectric Point: 4.3313

>AT124102 WP_012455043.1 NZ_CP039546:c3099406-3099119 [Methylorubrum populi]
MTELSPYDSAEFLDSDEAVAEYLAAAIEEGDAALFRRALGVAARARGMTQIARETGLSRESLYRALSDDGNPSLDTALRV
LNALNVRLTASVVPH

Download         Length: 288 bp

>AT124102 NZ_CP039546:c3099406-3099119 [Methylorubrum populi]
ATGACAGAGTTGAGCCCCTACGACTCGGCCGAATTCCTCGACAGCGACGAGGCCGTCGCTGAGTATCTCGCTGCAGCCAT
CGAGGAAGGCGATGCCGCGCTGTTTCGTCGGGCGCTTGGCGTGGCGGCGCGGGCCCGCGGCATGACCCAGATCGCCCGCG
AAACGGGCTTGTCGCGGGAAAGCCTCTACCGGGCGCTGTCGGATGACGGCAATCCCAGCCTCGACACGGCGTTGCGCGTC
CTCAACGCTCTGAACGTGCGCCTTACGGCTTCTGTTGTGCCTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References