Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2364724..2365372 Replicon chromosome
Accession NZ_CP039546
Organism Methylorubrum populi strain YC-XJ1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E8E01_RS11250 Protein ID WP_141951397.1
Coordinates 2364724..2364927 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E8E01_RS11255 Protein ID WP_141951398.1
Coordinates 2364965..2365372 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8E01_RS11230 2360244..2360759 + 516 WP_012454177.1 signal peptidase II -
E8E01_RS11235 2360928..2361620 + 693 WP_141951394.1 hypothetical protein -
E8E01_RS11240 2361768..2363150 + 1383 WP_141951395.1 insulinase family protein -
E8E01_RS11245 2363221..2364504 + 1284 WP_141951396.1 insulinase family protein -
E8E01_RS11250 2364724..2364927 + 204 WP_141951397.1 type II toxin-antitoxin system HicA family toxin Toxin
E8E01_RS11255 2364965..2365372 + 408 WP_141951398.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E8E01_RS11260 2365453..2366385 + 933 WP_012454181.1 ring-cleaving dioxygenase -
E8E01_RS11265 2366556..2367329 + 774 WP_012454182.1 ferredoxin--NADP reductase -
E8E01_RS11270 2367377..2368054 + 678 WP_141951399.1 dethiobiotin synthase -
E8E01_RS11275 2368061..2368420 - 360 WP_141951400.1 photosystem reaction center subunit H -
E8E01_RS11280 2368455..2368874 - 420 WP_012454185.1 response regulator -
E8E01_RS11285 2369142..2369816 + 675 WP_141951401.1 DUF1275 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(11-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-126)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7801.87 Da        Isoelectric Point: 11.4622

>T124099 WP_141951397.1 NZ_CP039546:2364724-2364927 [Methylorubrum populi]
VSYRNKETRGLIARLRQEGWIVARKGPGDHVQYKHPTKPGRVTLDTGRREQALGTLRSIYRQAGWEW

Download         Length: 204 bp

>T124099 NZ_CP039546:2364724-2364927 [Methylorubrum populi]
GTGTCATATCGCAACAAGGAAACGCGCGGTCTCATAGCCCGACTGCGTCAAGAGGGTTGGATCGTTGCCCGCAAGGGGCC
GGGTGACCATGTCCAGTACAAGCATCCGACGAAGCCGGGACGGGTGACGCTGGACACGGGGCGTCGGGAGCAGGCTCTGG
GCACGCTCCGCAGCATCTACCGGCAGGCGGGCTGGGAATGGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14355.22 Da        Isoelectric Point: 4.5467

>AT124099 WP_141951398.1 NZ_CP039546:2364965-2365372 [Methylorubrum populi]
MTRVVMLIHGGAGNYGASFPDFPGATTGADDLDELYRKAAEMLAFHVGGLVEDGEPVPRARSLDELRVDPVFVEDSRDAM
VGLIEVDLPGRAVRVNISVEESLLKRIDRAAEAAGESRSGFLAQAAKARLTSSVA

Download         Length: 408 bp

>AT124099 NZ_CP039546:2364965-2365372 [Methylorubrum populi]
ATGACGCGGGTCGTCATGCTGATACACGGCGGGGCCGGCAATTACGGTGCGTCCTTCCCGGACTTTCCCGGCGCGACGAC
AGGCGCCGACGATCTCGATGAACTCTACCGCAAGGCTGCCGAGATGCTGGCCTTCCATGTCGGCGGCTTAGTCGAGGACG
GTGAGCCGGTGCCGCGGGCGCGTTCCCTCGACGAGCTGCGCGTCGATCCGGTCTTCGTCGAGGACAGCCGGGACGCGATG
GTCGGCCTGATCGAGGTCGATCTGCCGGGGCGCGCCGTGCGGGTGAACATTTCGGTGGAGGAAAGTCTGCTCAAGCGCAT
CGACCGCGCGGCCGAGGCCGCGGGCGAGAGCCGATCCGGTTTCCTGGCCCAGGCCGCCAAGGCACGGCTGACCTCCTCAG
TGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References