Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4753167..4753837 Replicon chromosome
Accession NZ_CP039543
Organism Desulfovibrio marinus strain CS1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E8L03_RS20805 Protein ID WP_171268401.1
Coordinates 4753652..4753837 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E8L03_RS20800 Protein ID WP_171268400.1
Coordinates 4753167..4753574 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8L03_RS20785 4748654..4750237 + 1584 WP_144307010.1 glucose-6-phosphate dehydrogenase -
E8L03_RS20790 4750259..4752115 + 1857 WP_171268398.1 transketolase -
E8L03_RS20795 4752156..4753022 + 867 WP_171268399.1 transaldolase -
E8L03_RS20800 4753167..4753574 - 408 WP_171268400.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E8L03_RS20805 4753652..4753837 - 186 WP_171268401.1 type II toxin-antitoxin system HicA family toxin Toxin
E8L03_RS20815 4754292..4755941 - 1650 WP_171268402.1 glycosyltransferase -
E8L03_RS20820 4756040..4756642 + 603 WP_144305019.1 RlmE family RNA methyltransferase -
E8L03_RS20825 4756687..4757436 + 750 WP_144305018.1 YebC/PmpR family DNA-binding transcriptional regulator -
E8L03_RS20830 4757603..4758130 + 528 WP_144305017.1 crossover junction endodeoxyribonuclease RuvC -
E8L03_RS20835 4758205..4758801 + 597 WP_171268403.1 Holliday junction branch migration protein RuvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-124)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7029.12 Da        Isoelectric Point: 10.8073

>T124096 WP_171268401.1 NZ_CP039543:c4753837-4753652 [Desulfovibrio marinus]
MDSREVIQRLRDAGFEHVSTKGSHKKFRRGDKMVIVPDPKKDIPAGTLRSIYRQADLPWPP

Download         Length: 186 bp

>T124096 NZ_CP039543:c4753837-4753652 [Desulfovibrio marinus]
ATGGATAGCAGGGAAGTCATACAACGGCTGAGAGATGCAGGCTTTGAGCATGTATCCACCAAAGGCAGCCATAAAAAGTT
CCGCCGGGGCGATAAAATGGTGATCGTCCCTGATCCGAAAAAGGATATTCCGGCCGGCACCCTGCGCAGTATTTACCGTC
AGGCCGACCTACCCTGGCCCCCTTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14845.73 Da        Isoelectric Point: 4.3001

>AT124096 WP_171268400.1 NZ_CP039543:c4753574-4753167 [Desulfovibrio marinus]
MHYPIIVVPEPEQQAYTAVAPDIGEVASFGDSIEEALANLQEAVELYLEDAEEAPQPSKLEAVLEHEEVREHGGVVAFAD
LDLSFLDRKPVRLNVSLPSGLVKKIDEAARKRGMTRSGYLAWAADQAMARRQAEC

Download         Length: 408 bp

>AT124096 NZ_CP039543:c4753574-4753167 [Desulfovibrio marinus]
ATGCATTATCCGATCATTGTTGTTCCGGAGCCGGAGCAGCAGGCGTACACCGCCGTTGCTCCCGACATCGGCGAAGTCGC
GTCGTTCGGAGATTCCATCGAAGAAGCCTTGGCAAACCTGCAAGAGGCTGTGGAACTCTACCTGGAAGACGCAGAAGAAG
CACCCCAGCCATCCAAACTGGAGGCCGTGCTGGAGCACGAAGAAGTGCGAGAACACGGCGGCGTGGTGGCATTCGCAGAT
CTTGATCTCTCATTCCTGGACCGCAAACCGGTTAGGCTCAACGTGAGTCTCCCCAGCGGATTGGTTAAGAAGATCGACGA
GGCAGCCCGCAAACGCGGCATGACTCGTTCCGGCTATCTGGCTTGGGCCGCAGATCAAGCGATGGCGAGGAGACAGGCAG
AATGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References