Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2527817..2528358 Replicon chromosome
Accession NZ_CP039543
Organism Desulfovibrio marinus strain CS1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag E8L03_RS11200 Protein ID WP_171267394.1
Coordinates 2528035..2528358 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag E8L03_RS11195 Protein ID WP_171267393.1
Coordinates 2527817..2528038 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8L03_RS11175 2522953..2523957 - 1005 WP_171267389.1 ornithine cyclodeaminase -
E8L03_RS11180 2524326..2524856 - 531 WP_171267390.1 transporter -
E8L03_RS11185 2525454..2526299 - 846 WP_171267391.1 YkgJ family cysteine cluster protein -
E8L03_RS11190 2526458..2527651 - 1194 WP_171267392.1 NAD(P)/FAD-dependent oxidoreductase -
E8L03_RS11195 2527817..2528038 + 222 WP_171267393.1 antitoxin MazE family protein Antitoxin
E8L03_RS11200 2528035..2528358 + 324 WP_171267394.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E8L03_RS11205 2528609..2529562 + 954 WP_171267395.1 hypothetical protein -
E8L03_RS11210 2529938..2530900 + 963 WP_171267396.1 hydroxyacid dehydrogenase -
E8L03_RS11215 2531120..2532103 + 984 WP_171267397.1 4Fe-4S binding protein -
E8L03_RS11220 2532167..2533174 - 1008 WP_171267398.1 methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-107)

Antitoxin

Antitoxin MazE-like

(10-71)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11644.52 Da        Isoelectric Point: 5.6598

>T124095 WP_171267394.1 NZ_CP039543:2528035-2528358 [Desulfovibrio marinus]
MKRGDIVIVAMSGDYGKVRPALIVQNDVTLETHASIVVCPLTSHCIDAPLFRIPVAPTESNGLSTDSQIMVDKVSAVKRE
RVRDVVGSLDDETMVQVNRTIALWLGL

Download         Length: 324 bp

>T124095 NZ_CP039543:2528035-2528358 [Desulfovibrio marinus]
ATGAAACGGGGCGATATCGTGATCGTCGCCATGTCCGGGGATTACGGCAAGGTGCGTCCCGCGCTGATCGTCCAGAACGA
CGTGACCCTTGAGACGCACGCCAGCATCGTCGTCTGTCCACTCACCTCGCACTGCATCGACGCGCCGCTCTTCCGCATCC
CGGTCGCGCCTACCGAATCCAACGGCTTATCCACAGACTCGCAGATCATGGTCGATAAGGTCTCTGCCGTGAAGCGCGAG
CGAGTCCGCGATGTTGTCGGCTCCCTCGACGACGAGACAATGGTGCAAGTGAACCGCACCATTGCGCTGTGGCTTGGGCT
GTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8463.48 Da        Isoelectric Point: 5.7973

>AT124095 WP_171267393.1 NZ_CP039543:2527817-2528038 [Desulfovibrio marinus]
MPTNTLTSKQKMKQYRARMKERGLRAIQIWVPDTRSSEIHNALRRQSLLASQSADEQDVLDFLEDVSAWDDDA

Download         Length: 222 bp

>AT124095 NZ_CP039543:2527817-2528038 [Desulfovibrio marinus]
ATGCCCACGAACACCCTCACATCGAAGCAGAAGATGAAGCAGTACCGCGCCAGGATGAAGGAACGGGGCCTGCGGGCCAT
CCAGATCTGGGTGCCGGATACCCGCTCTTCCGAGATCCACAACGCCTTGCGGCGGCAGTCGCTTCTCGCCAGCCAGTCTG
CCGACGAACAGGATGTGCTCGATTTTCTGGAAGATGTTTCGGCCTGGGATGACGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References