124094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 316241..316763 Replicon plasmid pHB25-1-vir
Accession NZ_CP039526
Organism Klebsiella pneumoniae subsp. pneumoniae strain HB25-1

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag E8Q43_RS29655 Protein ID WP_004181778.1
Coordinates 316479..316763 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag E8Q43_RS29650 Protein ID WP_004181777.1
Coordinates 316241..316489 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8Q43_RS29630 311450..312271 - 822 WP_004181772.1 hypothetical protein -
E8Q43_RS29635 312333..312686 - 354 WP_004181774.1 hypothetical protein -
E8Q43_RS29640 312831..313817 - 987 WP_101992392.1 hypothetical protein -
E8Q43_RS29645 314151..315950 - 1800 WP_004181776.1 ATP-dependent helicase -
E8Q43_RS29650 316241..316489 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E8Q43_RS29655 316479..316763 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E8Q43_RS29660 316780..316881 - 102 Protein_340 IS200/IS605 family transposase -
E8Q43_RS29665 316917..318143 + 1227 WP_040209639.1 transposase -
E8Q43_RS29670 318414..318638 - 225 Protein_342 transposase -
E8Q43_RS29675 318717..319145 - 429 WP_077257669.1 IS200/IS605 family transposase -
E8Q43_RS29680 319181..320368 + 1188 WP_040209642.1 transposase -
E8Q43_RS29685 320467..321562 - 1096 Protein_345 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / blaTEM-1B / aac(3)-IId / qacE / aadA2 / dfrA12 / blaSHV-187 / catA1 iucA / iucB / iucC / iucD / iutA / rmpA 1..396373 396373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T124094 WP_004181778.1 NZ_CP039526:316479-316763 [Klebsiella pneumoniae subsp. pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T124094 NZ_CP039526:316479-316763 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT124094 WP_004181777.1 NZ_CP039526:316241-316489 [Klebsiella pneumoniae subsp. pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT124094 NZ_CP039526:316241-316489 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References