Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1015862..1016513 Replicon chromosome
Accession NZ_CP039520
Organism Acinetobacter baumannii strain TG22627

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag EA714_RS04910 Protein ID WP_000838146.1
Coordinates 1015862..1016044 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag EA714_RS04915 Protein ID WP_000966689.1
Coordinates 1016109..1016513 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EA714_RS04865 1011119..1011784 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
EA714_RS04870 1011789..1012178 + 390 WP_000008492.1 hypothetical protein -
EA714_RS04875 1012180..1012548 + 369 WP_000524231.1 hypothetical protein -
EA714_RS04880 1012557..1012961 + 405 WP_000248324.1 hypothetical protein -
EA714_RS04885 1012933..1013301 + 369 WP_000539752.1 hypothetical protein -
EA714_RS04890 1013303..1013701 + 399 WP_001132270.1 hypothetical protein -
EA714_RS04895 1013703..1013915 + 213 WP_000121166.1 hypothetical protein -
EA714_RS04900 1014023..1014952 + 930 WP_000094300.1 hypothetical protein -
EA714_RS04905 1014997..1015530 + 534 WP_001185622.1 hypothetical protein -
EA714_RS04910 1015862..1016044 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
EA714_RS04915 1016109..1016513 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EA714_RS04920 1016594..1016995 + 402 WP_000720591.1 hypothetical protein -
EA714_RS04925 1017056..1021021 + 3966 WP_000191304.1 tape measure protein -
EA714_RS04930 1021139..1021480 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 985469..1040084 54615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T124070 WP_000838146.1 NZ_CP039520:1015862-1016044 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T124070 NZ_CP039520:1015862-1016044 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT124070 WP_000966689.1 NZ_CP039520:1016109-1016513 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT124070 NZ_CP039520:1016109-1016513 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References