Detailed information of TA system TA124067

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 450406..451059
• Replicon: chromosome
• Accession: NZ_CP039518
• Organism: Acinetobacter baumannii strain TG22653

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EA719_RS02210
• Protein ID: WP_000607077.1
• Coordinates: 450670..451059 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: EA719_RS02205
• Protein ID: WP_001288210.1
• Coordinates: 450406..450663 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EA719_RS02185	445922..446929	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
EA719_RS02190	446948..447325	+	378	WP_001216380.1	50S ribosomal protein L17	-
EA719_RS02195	447507..448997	+	1491	WP_000415126.1	NAD(P)/FAD-dependent oxidoreductase	-
EA719_RS02200	449046..450218	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
EA719_RS02205	450406..450663	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
EA719_RS02210	450670..451059	+	390	WP_000607077.1	membrane protein	Toxin
EA719_RS02215	451829..452914	+	1086	WP_000049106.1	hypothetical protein	-
EA719_RS02220	452992..453558	+	567	WP_000651538.1	rhombosortase	-
EA719_RS02225	453746..455941	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T124067 WP_000607077.1 NZ_CP039518:450670-451059 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T124067 NZ_CP039518:450670-451059 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT124067 WP_001288210.1 NZ_CP039518:450406-450663 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT124067 NZ_CP039518:450406-450663 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7