Detailed information of TA system TA124066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 137196..137755
• Replicon: chromosome
• Accession: NZ_CP039517
• Organism: Salinivibrio sp. YCSC6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E8E00_RS14510
• Protein ID: WP_096632456.1
• Coordinates: 137477..137755 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N6J1W2
• Locus tag: E8E00_RS14505
• Protein ID: WP_069586513.1
• Coordinates: 137196..137477 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8E00_RS14470	132326..132787	-	462	WP_096632469.1	hypothetical protein	-
E8E00_RS14475	132876..133391	-	516	WP_096632467.1	GNAT family N-acetyltransferase	-
E8E00_RS14480	133491..133727	-	237	WP_096632464.1	hypothetical protein	-
E8E00_RS14485	133857..134408	-	552	WP_096632461.1	dihydrofolate reductase family protein	-
E8E00_RS14490	134645..135808	-	1164	WP_096632458.1	cytotoxin	-
E8E00_RS14495	136508..136786	-	279	WP_069586512.1	hypothetical protein	-
E8E00_RS14505	137196..137477	+	282	WP_069586513.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E8E00_RS14510	137477..137755	+	279	WP_096632456.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E8E00_RS14515	137923..138201	-	279	WP_096632453.1	hypothetical protein	-
E8E00_RS14520	138339..138860	-	522	WP_096632450.1	hypothetical protein	-
E8E00_RS14525	139468..141231	+	1764	WP_096632448.1	hypothetical protein	-
E8E00_RS14530	141331..142023	-	693	WP_069586652.1	aquaporin Z	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10695.32 Da
• Isoelectric Point: 4.3135

>T124066 WP_096632456.1 NZ_CP039517:137477-137755 [Salinivibrio sp. YCSC6]
MILWEEASLNDREKIFEFLYDFNPEVAEKTDSLIEAKVENLLEQPSMGVQRDGIRGRLLIIPEISMIVSYSVEGDIIQVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T124066 NZ_CP039517:137477-137755 [Salinivibrio sp. YCSC6]
ATGATTTTATGGGAAGAAGCGTCACTTAACGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGAGGTGGC
AGAAAAAACTGACAGCCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTCAATGGGCGTACAACGAGATGGCA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTCGGTCGAGGGCGATATCATCCAAGTCATG
CGTGTACTGCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10911.20 Da
• Isoelectric Point: 8.0533

>AT124066 WP_069586513.1 NZ_CP039517:137196-137477 [Salinivibrio sp. YCSC6]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQAAQSR
MEERKARIRNRGK

Nucleotide

• Length: 282 bp

>AT124066 NZ_CP039517:137196-137477 [Salinivibrio sp. YCSC6]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCACAACAAATGGCTGAGAGCCAAGGGCGCAC
ACTGAGTGATGCTTGCCGTGAACTTACTGAGCAACTTGCTGAACAACAGAGAAAAACATTATCTCACGATGCGTGGTTAA
CAGAACAAGTAAACCTAGCGTTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAGCTGCTCAATCTCGA
ATGGAAGAGCGTAAAGCCAGAATCCGTAATCGAGGCAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1N6J1W2