Detailed information of TA system TA124064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1990156..1990700
• Replicon: chromosome
• Accession: NZ_CP039516
• Organism: Salinivibrio sp. YCSC6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1V3HA63
• Locus tag: E8E00_RS09125
• Protein ID: WP_021024563.1
• Coordinates: 1990156..1990455 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E8E00_RS09130
• Protein ID: WP_096631634.1
• Coordinates: 1990443..1990700 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8E00_RS09095	1985249..1985716	-	468	WP_077457637.1	Lrp/AsnC family transcriptional regulator	-
E8E00_RS09100	1985847..1986911	+	1065	WP_096631320.1	PLP-dependent cysteine synthase family protein	-
E8E00_RS09105	1986955..1987452	-	498	WP_096631318.1	DUF1003 domain-containing protein	-
E8E00_RS09110	1987564..1987980	-	417	WP_069588005.1	nuclear transport factor 2 family protein	-
E8E00_RS09115	1988020..1989402	-	1383	WP_096631637.1	ATP-dependent RNA helicase DbpA	-
E8E00_RS09120	1989709..1990080	+	372	WP_046073855.1	acyl-CoA thioesterase	-
E8E00_RS09125	1990156..1990455	-	300	WP_021024563.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E8E00_RS09130	1990443..1990700	-	258	WP_096631634.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E8E00_RS09135	1990790..1991314	-	525	WP_096631316.1	RES family NAD+ phosphorylase	-
E8E00_RS09140	1991496..1992191	+	696	WP_096631314.1	7-cyano-7-deazaguanine synthase QueC	-
E8E00_RS09145	1992277..1995426	-	3150	WP_096631312.1	multidrug efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11335.15 Da
• Isoelectric Point: 4.5994

>T124064 WP_021024563.1 NZ_CP039516:c1990455-1990156 [Salinivibrio sp. YCSC6]
MAQIVWTEPALADLNDVAEYVALDNLVAAKALVQAAFTAVERLVLFPDSGRVPPELPHLNYREVVVNPCRIFYKQEEDTV
FILFVMRSEQDLRKFLLSR

Nucleotide

• Length: 300 bp

>T124064 NZ_CP039516:c1990455-1990156 [Salinivibrio sp. YCSC6]
ATGGCTCAAATAGTTTGGACTGAGCCTGCGTTGGCAGATCTGAATGACGTTGCTGAATATGTTGCACTGGACAACCTGGT
TGCAGCTAAAGCGCTAGTGCAAGCGGCCTTTACCGCAGTGGAGCGGTTAGTGCTTTTTCCTGATTCTGGTCGAGTGCCAC
CTGAACTACCGCACTTGAATTATCGAGAGGTGGTGGTGAATCCTTGTCGTATTTTCTATAAGCAAGAAGAAGACACGGTG
TTTATCTTATTCGTCATGCGTTCAGAACAGGATCTACGTAAGTTCTTACTATCGCGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9784.42 Da
• Isoelectric Point: 9.5940

>AT124064 WP_096631634.1 NZ_CP039516:c1990700-1990443 [Salinivibrio sp. YCSC6]
MKVELVTTLKRQATKILSELKANKEPVLITEHGKPSAYLLSVDDYELMQRRLAILEGIARGERAITEEKLVSHHDAKEQM
SRWLK

Nucleotide

• Length: 258 bp

>AT124064 NZ_CP039516:c1990700-1990443 [Salinivibrio sp. YCSC6]
ATGAAAGTAGAACTTGTGACCACACTGAAGCGTCAGGCAACCAAAATTTTGTCTGAATTGAAGGCGAATAAAGAGCCTGT
TTTGATCACCGAACATGGTAAGCCTTCAGCATACTTATTAAGTGTGGATGATTACGAATTAATGCAGCGCCGTCTTGCTA
TCTTAGAAGGGATCGCGCGTGGCGAGCGCGCCATTACTGAAGAGAAGCTCGTGAGTCACCATGATGCCAAGGAACAAATG
TCCAGATGGCTCAAATAG

Structures

Toxin

• AlphaFold DB: A0A1V3HA63