Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4226925..4227706 | Replicon | chromosome |
| Accession | NZ_CP039502 | ||
| Organism | Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A0R9NZI3 |
| Locus tag | SEEB0189_RS20930 | Protein ID | WP_000625912.1 |
| Coordinates | 4226925..4227416 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | M7RNV8 |
| Locus tag | SEEB0189_RS20935 | Protein ID | WP_001110450.1 |
| Coordinates | 4227413..4227706 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SEEB0189_RS20905 (4222065) | 4222065..4224503 | - | 2439 | WP_020839686.1 | F4 (K88) fimbrial usher FaeD | - |
| SEEB0189_RS20910 (4224513) | 4224513..4225052 | - | 540 | WP_000721295.1 | type 1 fimbrial protein | - |
| SEEB0189_RS20915 (4225087) | 4225087..4225377 | - | 291 | WP_000773468.1 | PapB/FocB family fimbrial expression transcriptional regulator | - |
| SEEB0189_RS20920 (4225960) | 4225960..4226187 | + | 228 | WP_001519955.1 | hypothetical protein | - |
| SEEB0189_RS20925 (4226462) | 4226462..4226710 | - | 249 | Protein_4008 | IS481 family transposase | - |
| SEEB0189_RS20930 (4226925) | 4226925..4227416 | - | 492 | WP_000625912.1 | GNAT family N-acetyltransferase | Toxin |
| SEEB0189_RS20935 (4227413) | 4227413..4227706 | - | 294 | WP_001110450.1 | DUF1778 domain-containing protein | Antitoxin |
| SEEB0189_RS20940 (4228023) | 4228023..4228245 | + | 223 | Protein_4011 | hypothetical protein | - |
| SEEB0189_RS20945 (4228510) | 4228510..4229385 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| SEEB0189_RS20950 (4229382) | 4229382..4229669 | + | 288 | WP_001541332.1 | transcriptional regulator RtsB | - |
| SEEB0189_RS20955 (4229809) | 4229809..4230183 | + | 375 | WP_226952343.1 | Ig-like domain-containing protein | - |
| SEEB0189_RS20960 (4230478) | 4230478..4231383 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | faeI / faeH / faeF / faeE / faeD / faeC | 4214392..4230183 | 15791 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17606.43 Da Isoelectric Point: 7.7297
>T124059 WP_000625912.1 NZ_CP039502:c4227416-4226925 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T124059 NZ_CP039502:c4227416-4226925 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10949.56 Da Isoelectric Point: 8.6141
>AT124059 WP_001110450.1 NZ_CP039502:c4227706-4227413 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT124059 NZ_CP039502:c4227706-4227413 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R9NZI3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0R9PGG6 |