Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4088294..4088810 Replicon chromosome
Accession NZ_CP039502
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag SEEB0189_RS20205 Protein ID WP_000220578.1
Coordinates 4088294..4088578 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag SEEB0189_RS20210 Protein ID WP_000212724.1
Coordinates 4088568..4088810 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEB0189_RS20190 (4083410) 4083410..4085062 + 1653 WP_020839659.1 alpha,alpha-phosphotrehalase -
SEEB0189_RS20195 (4085471) 4085471..4087609 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
SEEB0189_RS20200 (4087826) 4087826..4088290 + 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
SEEB0189_RS20205 (4088294) 4088294..4088578 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SEEB0189_RS20210 (4088568) 4088568..4088810 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SEEB0189_RS20215 (4088888) 4088888..4090801 - 1914 WP_001212135.1 BglG family transcription antiterminator -
SEEB0189_RS20220 (4090818) 4090818..4091558 - 741 WP_023193113.1 KDGP aldolase family protein -
SEEB0189_RS20225 (4091555) 4091555..4092673 - 1119 WP_020839660.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
SEEB0189_RS20230 (4092657) 4092657..4093790 - 1134 WP_020839661.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T124058 WP_000220578.1 NZ_CP039502:c4088578-4088294 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T124058 NZ_CP039502:c4088578-4088294 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT124058 WP_000212724.1 NZ_CP039502:c4088810-4088568 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT124058 NZ_CP039502:c4088810-4088568 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References