Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3997620..3998196 Replicon chromosome
Accession NZ_CP039502
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)


Gene name shpA Uniprot ID A0A4D6PC34
Locus tag SEEB0189_RS19780 Protein ID WP_020839635.1
Coordinates 3997909..3998196 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag SEEB0189_RS19775 Protein ID WP_000063142.1
Coordinates 3997620..3997922 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEB0189_RS19760 (3994130) 3994130..3996280 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
SEEB0189_RS19765 (3996375) 3996375..3996578 + 204 WP_000460616.1 YbdD/YjiX family protein -
SEEB0189_RS19770 (3996589) 3996589..3997545 + 957 WP_000187838.1 GTPase -
SEEB0189_RS19775 (3997620) 3997620..3997922 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
SEEB0189_RS19780 (3997909) 3997909..3998196 - 288 WP_020839635.1 BrnT family toxin Toxin
SEEB0189_RS19785 (3998627) 3998627..4000468 + 1842 WP_020839636.1 nuclease-related domain-containing DEAD/DEAH box helicase -
SEEB0189_RS19790 (4001081) 4001081..4001656 + 576 WP_020839637.1 restriction endonuclease subunit S -
SEEB0189_RS19795 (4001661) 4001661..4002914 + 1254 WP_020839638.1 N-6 DNA methylase -
SEEB0189_RS23230 (4002946) 4002946..4003080 - 135 WP_001055726.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11241.75 Da        Isoelectric Point: 8.0998

>T124057 WP_020839635.1 NZ_CP039502:c3998196-3997909 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVICIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T124057 NZ_CP039502:c3998196-3997909 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
TCTGGTATTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTTGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCTGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT124057 WP_000063142.1 NZ_CP039502:c3997922-3997620 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT124057 NZ_CP039502:c3997922-3997620 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6PC34

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References