Detailed information of TA system TA124056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3401480..3402100
• Replicon: chromosome
• Accession: NZ_CP039502
• Organism: Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: SEEB0189_RS16960
• Protein ID: WP_001280991.1
• Coordinates: 3401882..3402100 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: SEEB0189_RS16955
• Protein ID: WP_000344807.1
• Coordinates: 3401480..3401854 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEB0189_RS16945 (3396619)	3396619..3397812	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
SEEB0189_RS16950 (3397835)	3397835..3400984	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
SEEB0189_RS16955 (3401480)	3401480..3401854	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
SEEB0189_RS16960 (3401882)	3401882..3402100	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
SEEB0189_RS16965 (3402279)	3402279..3402830	+	552	WP_001278793.1	maltose O-acetyltransferase	-
SEEB0189_RS16970 (3402947)	3402947..3403417	+	471	WP_000136181.1	YlaC family protein	-
SEEB0189_RS16975 (3403473)	3403473..3403613	-	141	WP_020839525.1	type B 50S ribosomal protein L36	-
SEEB0189_RS16980 (3403619)	3403619..3403879	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
SEEB0189_RS16985 (3404104)	3404104..3405654	+	1551	WP_000213142.1	EAL domain-containing protein	-
SEEB0189_RS16995 (3405885)	3405885..3406274	+	390	WP_000961285.1	MGMT family protein	-
SEEB0189_RS17000 (3406307)	3406307..3406876	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T124056 WP_001280991.1 NZ_CP039502:3401882-3402100 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T124056 NZ_CP039502:3401882-3402100 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT124056 WP_000344807.1 NZ_CP039502:3401480-3401854 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT124056 NZ_CP039502:3401480-3401854 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0