Detailed information of TA system TA124055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2349960..2350482
• Replicon: chromosome
• Accession: NZ_CP039502
• Organism: Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: V7IL40
• Locus tag: SEEB0189_RS11740
• Protein ID: WP_000221345.1
• Coordinates: 2350198..2350482 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: SEEB0189_RS11735
• Protein ID: WP_000885424.1
• Coordinates: 2349960..2350208 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEB0189_RS11705 (2345133)	2345133..2346599	+	1467	WP_020839351.1	hypothetical protein	-
SEEB0189_RS11710 (2346875)	2346875..2347063	+	189	WP_001276020.1	DUF29 family protein	-
SEEB0189_RS11715 (2347338)	2347338..2347670	-	333	WP_020839352.1	DUF1493 family protein	-
SEEB0189_RS11720 (2348321)	2348321..2348437	-	117	Protein_2205	IS110 family transposase	-
SEEB0189_RS11725 (2348802)	2348802..2349191	+	390	WP_001044696.1	hypothetical protein	-
SEEB0189_RS11730 (2349194)	2349194..2349547	+	354	WP_000418733.1	hypothetical protein	-
SEEB0189_RS11735 (2349960)	2349960..2350208	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SEEB0189_RS11740 (2350198)	2350198..2350482	+	285	WP_000221345.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SEEB0189_RS11745 (2350653)	2350653..2351042	+	390	WP_012218813.1	RidA family protein	-
SEEB0189_RS11750 (2351094)	2351094..2352173	-	1080	WP_020839353.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
SEEB0189_RS11755 (2352366)	2352366..2352854	-	489	WP_001293637.1	MarR family winged helix-turn-helix transcriptional regulator	-
SEEB0189_RS11760 (2352899)	2352899..2354407	+	1509	WP_020839354.1	FAD-dependent monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2345136..2357264	12128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11043.79 Da
• Isoelectric Point: 10.6500

>T124055 WP_000221345.1 NZ_CP039502:2350198-2350482 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Nucleotide

• Length: 285 bp

>T124055 NZ_CP039502:2350198-2350482 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT124055 WP_000885424.1 NZ_CP039502:2349960-2350208 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT124055 NZ_CP039502:2349960-2350208 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: A0A5Y2FFA8

Antitoxin

• AlphaFold DB: A0A5I0WPN5