Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 886889..887553 | Replicon | chromosome |
| Accession | NZ_CP039502 | ||
| Organism | Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A4D6P388 |
| Locus tag | SEEB0189_RS04740 | Protein ID | WP_020839085.1 |
| Coordinates | 887230..887553 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A4D6P3F3 |
| Locus tag | SEEB0189_RS04735 | Protein ID | WP_020839084.1 |
| Coordinates | 886889..887209 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SEEB0189_RS04690 (882245) | 882245..882949 | + | 705 | WP_020839075.1 | WYL domain-containing protein | - |
| SEEB0189_RS04695 (882949) | 882949..883518 | + | 570 | WP_020839076.1 | hypothetical protein | - |
| SEEB0189_RS04700 (883555) | 883555..884007 | + | 453 | WP_020839077.1 | hypothetical protein | - |
| SEEB0189_RS04705 (884004) | 884004..884453 | + | 450 | WP_020839078.1 | IrmA family protein | - |
| SEEB0189_RS04710 (884525) | 884525..884755 | + | 231 | WP_020839079.1 | DUF905 domain-containing protein | - |
| SEEB0189_RS04715 (884854) | 884854..885675 | + | 822 | WP_020839080.1 | DUF932 domain-containing protein | - |
| SEEB0189_RS04720 (885706) | 885706..886149 | + | 444 | WP_020839081.1 | antirestriction protein | - |
| SEEB0189_RS04725 (886158) | 886158..886640 | + | 483 | WP_023193097.1 | DNA repair protein RadC | - |
| SEEB0189_RS04730 (886649) | 886649..886870 | + | 222 | WP_020839083.1 | DUF987 domain-containing protein | - |
| SEEB0189_RS04735 (886889) | 886889..887209 | + | 321 | WP_020839084.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| SEEB0189_RS04740 (887230) | 887230..887553 | + | 324 | WP_020839085.1 | TA system toxin CbtA family protein | Toxin |
| SEEB0189_RS04745 (887893) | 887893..888699 | - | 807 | WP_077909649.1 | DUF1460 domain-containing protein | - |
| SEEB0189_RS04750 (888890) | 888890..889060 | + | 171 | Protein_845 | tRNA(fMet)-specific endonuclease VapC | - |
| SEEB0189_RS04755 (889869) | 889869..890405 | + | 537 | WP_001038502.1 | STM3031 family outer membrane protein | - |
| SEEB0189_RS04760 (890452) | 890452..891084 | + | 633 | WP_000835265.1 | YfdX family protein | - |
| SEEB0189_RS04765 (891803) | 891803..892384 | + | 582 | WP_001244652.1 | fimbrial protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 843766..898202 | 54436 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12219.08 Da Isoelectric Point: 5.6838
>T124045 WP_020839085.1 NZ_CP039502:887230-887553 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MKTLPATISRAAEPCLSPVAVWQTLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTSYLTIIDIMRARCDLGLLNRN
MKTLPATISRAAEPCLSPVAVWQTLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTSYLTIIDIMRARCDLGLLNRN
Download Length: 324 bp
>T124045 NZ_CP039502:887230-887553 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGAAAACTCTACCTGCTACAATTTCGCGTGCGGCGGAACCCTGCCTGTCGCCCGTGGCTGTCTGGCAAACTTTACTGAC
ACGCCTGCTGGAACAGCACTATGGTCTGACACTGAACGATACGCCGTTCAGTGATGAAACCGTTATAAAGGAACATATCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGTCATATCTCACGATTATTGATATCATGAGGGCCCGCTGCGATCTGGGTTTATTAAATCGTAA
TTAG
ATGAAAACTCTACCTGCTACAATTTCGCGTGCGGCGGAACCCTGCCTGTCGCCCGTGGCTGTCTGGCAAACTTTACTGAC
ACGCCTGCTGGAACAGCACTATGGTCTGACACTGAACGATACGCCGTTCAGTGATGAAACCGTTATAAAGGAACATATCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGTCATATCTCACGATTATTGATATCATGAGGGCCCGCTGCGATCTGGGTTTATTAAATCGTAA
TTAG
Antitoxin
Download Length: 107 a.a. Molecular weight: 11966.50 Da Isoelectric Point: 6.9464
>AT124045 WP_020839084.1 NZ_CP039502:886889-887209 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MSSNVTWGLQRDITPRLGARLVQEGNRLHYLADRASITGKLSDAECRRLDETFPHFISQMESMLTTGEMNPRHAHCVTLY
HNGFTCEADTLGSCGYVYIAVYPSQR
MSSNVTWGLQRDITPRLGARLVQEGNRLHYLADRASITGKLSDAECRRLDETFPHFISQMESMLTTGEMNPRHAHCVTLY
HNGFTCEADTLGSCGYVYIAVYPSQR
Download Length: 321 bp
>AT124045 NZ_CP039502:886889-887209 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGAGCAGTAATGTCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCCCGTCTGGTACAGGAGGGCAACCG
GCTACACTATCTGGCTGACCGGGCAAGCATCACTGGTAAATTAAGTGACGCCGAATGCCGGAGGCTGGATGAAACATTCC
CGCACTTTATCAGTCAGATGGAGTCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGCGTCACCCTGTAC
CACAATGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCTGTTTATCCCAGTCAACGCTA
A
ATGAGCAGTAATGTCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCCCGTCTGGTACAGGAGGGCAACCG
GCTACACTATCTGGCTGACCGGGCAAGCATCACTGGTAAATTAAGTGACGCCGAATGCCGGAGGCTGGATGAAACATTCC
CGCACTTTATCAGTCAGATGGAGTCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGCGTCACCCTGTAC
CACAATGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCTGTTTATCCCAGTCAACGCTA
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4D6P388 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4D6P3F3 |