Detailed information of TA system TA124044

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 834356..835016
• Replicon: chromosome
• Accession: NZ_CP039502
• Organism: Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: Q57K70
• Locus tag: SEEB0189_RS04460
• Protein ID: WP_000244756.1
• Coordinates: 834603..835016 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: SEEB0189_RS04455
• Protein ID: WP_000351186.1
• Coordinates: 834356..834622 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEB0189_RS04435 (830285)	830285..831718	-	1434	WP_001230141.1	6-phospho-beta-glucosidase BglA	-
SEEB0189_RS04440 (831876)	831876..832187	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
SEEB0189_RS04445 (832351)	832351..833010	+	660	WP_000250289.1	hemolysin III family protein	-
SEEB0189_RS04450 (833126)	833126..834106	-	981	WP_020839040.1	tRNA-modifying protein YgfZ	-
SEEB0189_RS04455 (834356)	834356..834622	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
SEEB0189_RS04460 (834603)	834603..835016	+	414	WP_000244756.1	protein YgfX	Toxin
SEEB0189_RS04465 (835069)	835069..835590	-	522	WP_001055885.1	flavodoxin FldB	-
SEEB0189_RS04470 (835703)	835703..836599	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
SEEB0189_RS04475 (836623)	836623..837336	+	714	WP_001748680.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
SEEB0189_RS04480 (837342)	837342..839075	+	1734	WP_001748681.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16183.15 Da
• Isoelectric Point: 10.7537

>T124044 WP_000244756.1 NZ_CP039502:834603-835016 [Salmonella enterica subsp. enterica serovar Bareilly str.]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T124044 NZ_CP039502:834603-835016 [Salmonella enterica subsp. enterica serovar Bareilly str.]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT124044 WP_000351186.1 NZ_CP039502:834356-834622 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT124044 NZ_CP039502:834356-834622 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A3Z1E9V5

Antitoxin

• AlphaFold DB: A0A5I0YWH4