Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 204192..204952 | Replicon | chromosome |
| Accession | NZ_CP039502 | ||
| Organism | Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A4D6P0H3 |
| Locus tag | SEEB0189_RS01405 | Protein ID | WP_000533911.1 |
| Coordinates | 204467..204952 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A4D6P4V8 |
| Locus tag | SEEB0189_RS01400 | Protein ID | WP_020838553.1 |
| Coordinates | 204192..204479 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SEEB0189_RS01380 (199597) | 199597..200508 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| SEEB0189_RS01385 (200518) | 200518..202587 | + | 2070 | WP_001291736.1 | glycine--tRNA ligase subunit beta | - |
| SEEB0189_RS01390 (202977) | 202977..203375 | + | 399 | Protein_187 | IS3 family transposase | - |
| SEEB0189_RS01395 (203547) | 203547..204014 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| SEEB0189_RS01400 (204192) | 204192..204479 | + | 288 | WP_020838553.1 | DUF1778 domain-containing protein | Antitoxin |
| SEEB0189_RS01405 (204467) | 204467..204952 | + | 486 | WP_000533911.1 | GNAT family N-acetyltransferase | Toxin |
| SEEB0189_RS01410 (205326) | 205326..205865 | - | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
| SEEB0189_RS01415 (206038) | 206038..206250 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| SEEB0189_RS01420 (206538) | 206538..206828 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| SEEB0189_RS01425 (207267) | 207267..207977 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| SEEB0189_RS01430 (208027) | 208027..209001 | - | 975 | WP_000804690.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| SEEB0189_RS01435 (209220) | 209220..209882 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17751.50 Da Isoelectric Point: 10.0066
>T124042 WP_000533911.1 NZ_CP039502:204467-204952 [Salmonella enterica subsp. enterica serovar Bareilly str.]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVYLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVYLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T124042 NZ_CP039502:204467-204952 [Salmonella enterica subsp. enterica serovar Bareilly str.]
GTGGGGCGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCTATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
GTGGGGCGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCTATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10892.57 Da Isoelectric Point: 4.8604
>AT124042 WP_020838553.1 NZ_CP039502:204192-204479 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWGV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWGV
Download Length: 288 bp
>AT124042 NZ_CP039502:204192-204479 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGGCGTGTAA
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGGCGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4D6P0H3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4D6P4V8 |