Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 28627..29152 Replicon plasmid pCFSAN000189
Accession NZ_CP039501
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)


Gene name ccdB Uniprot ID A0A4D6P1W7
Locus tag SEEB0189_RS00165 Protein ID WP_020833585.1
Coordinates 28847..29152 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag SEEB0189_RS00160 Protein ID WP_000813642.1
Coordinates 28627..28845 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEEB0189_RS00145 (SEEB0189_00135) 24675..25727 + 1053 WP_020833588.1 Ig-like domain-containing protein -
SEEB0189_RS00150 (SEEB0189_00140) 25926..26648 + 723 WP_000742239.1 LuxR family transcriptional regulator -
SEEB0189_RS00155 (SEEB0189_00145) 27391..27807 + 417 WP_001672640.1 lysozyme inhibitor LprI family protein -
SEEB0189_RS00160 (SEEB0189_00150) 28627..28845 + 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
SEEB0189_RS00165 (SEEB0189_00155) 28847..29152 + 306 WP_020833585.1 type II toxin-antitoxin system toxin CcdB Toxin
SEEB0189_RS00170 29210..29423 + 214 Protein_33 hypothetical protein -
SEEB0189_RS00175 (SEEB0189_00160) 29461..30243 + 783 WP_020833584.1 site-specific integrase -
SEEB0189_RS00180 (SEEB0189_00165) 30394..31335 - 942 WP_000728920.1 Rpn family recombination-promoting nuclease/putative transposase -
SEEB0189_RS00185 (SEEB0189_00170) 31966..32220 + 255 WP_001749329.1 hypothetical protein -
SEEB0189_RS23195 32508..32606 + 99 WP_020833583.1 DinQ-like type I toxin DqlB -
SEEB0189_RS00190 (SEEB0189_00175) 32909..34114 + 1206 WP_000427674.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..81815 81815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11661.45 Da        Isoelectric Point: 5.6919

>T124041 WP_020833585.1 NZ_CP039501:28847-29152 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MQFKVYTYKRESRYTLFVDVQSDIIDTPGRRMVIPLTSARLLSDKVSRELYPVVHIGDEIWRLMTTDMASVPASVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T124041 NZ_CP039501:28847-29152 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGCAGTTTAAGGTTTACACCTATAAAAGGGAGAGTCGCTACACCCTGTTCGTGGATGTCCAGAGTGACATTATCGACAC
CCCCGGACGGCGGATGGTGATCCCGCTGACCAGCGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCTGTGG
TACATATCGGGGATGAGATCTGGCGTCTGATGACCACAGATATGGCCAGTGTGCCGGCCTCAGTCATCGGGGAAGAGGTG
GCCGATCTCAGTCACCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8328.19 Da        Isoelectric Point: 4.5358

>AT124041 WP_000813642.1 NZ_CP039501:28627-28845 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRNW

Download         Length: 219 bp

>AT124041 NZ_CP039501:28627-28845 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6P1W7

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References