Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 28627..29152 | Replicon | plasmid pCFSAN000189 |
Accession | NZ_CP039501 | ||
Organism | Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | A0A4D6P1W7 |
Locus tag | SEEB0189_RS00165 | Protein ID | WP_020833585.1 |
Coordinates | 28847..29152 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | I3VZQ6 |
Locus tag | SEEB0189_RS00160 | Protein ID | WP_000813642.1 |
Coordinates | 28627..28845 (+) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SEEB0189_RS00145 (SEEB0189_00135) | 24675..25727 | + | 1053 | WP_020833588.1 | Ig-like domain-containing protein | - |
SEEB0189_RS00150 (SEEB0189_00140) | 25926..26648 | + | 723 | WP_000742239.1 | LuxR family transcriptional regulator | - |
SEEB0189_RS00155 (SEEB0189_00145) | 27391..27807 | + | 417 | WP_001672640.1 | lysozyme inhibitor LprI family protein | - |
SEEB0189_RS00160 (SEEB0189_00150) | 28627..28845 | + | 219 | WP_000813642.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
SEEB0189_RS00165 (SEEB0189_00155) | 28847..29152 | + | 306 | WP_020833585.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
SEEB0189_RS00170 | 29210..29423 | + | 214 | Protein_33 | hypothetical protein | - |
SEEB0189_RS00175 (SEEB0189_00160) | 29461..30243 | + | 783 | WP_020833584.1 | site-specific integrase | - |
SEEB0189_RS00180 (SEEB0189_00165) | 30394..31335 | - | 942 | WP_000728920.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
SEEB0189_RS00185 (SEEB0189_00170) | 31966..32220 | + | 255 | WP_001749329.1 | hypothetical protein | - |
SEEB0189_RS23195 | 32508..32606 | + | 99 | WP_020833583.1 | DinQ-like type I toxin DqlB | - |
SEEB0189_RS00190 (SEEB0189_00175) | 32909..34114 | + | 1206 | WP_000427674.1 | AAA family ATPase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | - | 1..81815 | 81815 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11661.45 Da Isoelectric Point: 5.6919
>T124041 WP_020833585.1 NZ_CP039501:28847-29152 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MQFKVYTYKRESRYTLFVDVQSDIIDTPGRRMVIPLTSARLLSDKVSRELYPVVHIGDEIWRLMTTDMASVPASVIGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYTYKRESRYTLFVDVQSDIIDTPGRRMVIPLTSARLLSDKVSRELYPVVHIGDEIWRLMTTDMASVPASVIGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T124041 NZ_CP039501:28847-29152 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGCAGTTTAAGGTTTACACCTATAAAAGGGAGAGTCGCTACACCCTGTTCGTGGATGTCCAGAGTGACATTATCGACAC
CCCCGGACGGCGGATGGTGATCCCGCTGACCAGCGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCTGTGG
TACATATCGGGGATGAGATCTGGCGTCTGATGACCACAGATATGGCCAGTGTGCCGGCCTCAGTCATCGGGGAAGAGGTG
GCCGATCTCAGTCACCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCTGGGGGATTTGA
ATGCAGTTTAAGGTTTACACCTATAAAAGGGAGAGTCGCTACACCCTGTTCGTGGATGTCCAGAGTGACATTATCGACAC
CCCCGGACGGCGGATGGTGATCCCGCTGACCAGCGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCTGTGG
TACATATCGGGGATGAGATCTGGCGTCTGATGACCACAGATATGGCCAGTGTGCCGGCCTCAGTCATCGGGGAAGAGGTG
GCCGATCTCAGTCACCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCTGGGGGATTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8328.19 Da Isoelectric Point: 4.5358
>AT124041 WP_000813642.1 NZ_CP039501:28627-28845 [Salmonella enterica subsp. enterica serovar Bareilly str.]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRNW
Download Length: 219 bp
>AT124041 NZ_CP039501:28627-28845 [Salmonella enterica subsp. enterica serovar Bareilly str.]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4D6P1W7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A600YYQ0 |