Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 19620..20145 Replicon plasmid pCFSAN000952
Accession NZ_CP039485
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000952

Toxin (Protein)


Gene name ccdB Uniprot ID A0A4D6P1W7
Locus tag E3399_RS23135 Protein ID WP_020833585.1
Coordinates 19620..19925 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag E3399_RS23140 Protein ID WP_000813642.1
Coordinates 19927..20145 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3399_RS23115 14659..15864 - 1206 WP_000427674.1 AAA family ATPase -
E3399_RS23120 16552..16806 - 255 WP_001749329.1 hypothetical protein -
E3399_RS23125 17437..18378 + 942 WP_000728920.1 Rpn family recombination-promoting nuclease/putative transposase -
E3399_RS23130 18529..19311 - 783 WP_020833584.1 site-specific integrase -
E3399_RS23135 19620..19925 - 306 WP_020833585.1 type II toxin-antitoxin system toxin CcdB Toxin
E3399_RS23140 19927..20145 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
E3399_RS23145 20965..21336 - 372 WP_100215268.1 DUF1311 domain-containing protein -
E3399_RS23150 22124..22846 - 723 WP_000742239.1 LuxR C-terminal-related transcriptional regulator -
E3399_RS23155 23045..24097 - 1053 WP_020833588.1 Ig-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81929 81929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T124031 WP_020833585.1 NZ_CP039485:c19925-19620 [Salmonella enterica subsp. enterica serovar Bareilly str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T124031 NZ_CP039485:c19925-19620 [Salmonella enterica subsp. enterica serovar Bareilly str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT124031 WP_000813642.1 NZ_CP039485:c20145-19927 [Salmonella enterica subsp. enterica serovar Bareilly str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT124031 NZ_CP039485:c20145-19927 [Salmonella enterica subsp. enterica serovar Bareilly str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6P1W7

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References