Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 43743..44268 Replicon plasmid pCFSAN000958
Accession NZ_CP039481
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000958

Toxin (Protein)


Gene name ccdB Uniprot ID A0A4D6P1W7
Locus tag E3398_RS23220 Protein ID WP_020833585.1
Coordinates 43963..44268 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag E3398_RS23215 Protein ID WP_000813642.1
Coordinates 43743..43961 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3398_RS23195 39664..40716 + 1053 WP_020833588.1 Ig-like domain-containing protein -
E3398_RS23200 40915..41217 + 303 WP_136585220.1 autoinducer binding domain-containing protein -
E3398_RS23205 41198..41764 + 567 WP_136585221.1 autoinducer binding domain-containing protein -
E3398_RS23210 42552..42923 + 372 WP_100215268.1 DUF1311 domain-containing protein -
E3398_RS23215 43743..43961 + 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
E3398_RS23220 43963..44268 + 306 WP_020833585.1 type II toxin-antitoxin system toxin CcdB Toxin
E3398_RS23225 44577..45359 + 783 WP_020833584.1 site-specific integrase -
E3398_RS23230 45510..46451 - 942 WP_000728920.1 Rpn family recombination-promoting nuclease/putative transposase -
E3398_RS23235 47082..47336 + 255 WP_001749329.1 hypothetical protein -
E3398_RS23240 48025..49230 + 1206 WP_000427674.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81938 81938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T124028 WP_020833585.1 NZ_CP039481:43963-44268 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T124028 NZ_CP039481:43963-44268 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT124028 WP_000813642.1 NZ_CP039481:43743-43961 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT124028 NZ_CP039481:43743-43961 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6P1W7

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References