Detailed information of TA system TA124026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 54409..54956
• Replicon: plasmid pCFSAN000960
• Accession: NZ_CP039479
• Organism: Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000960

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4D6NZF1
• Locus tag: E3395_RS23335
• Protein ID: WP_000970006.1
• Coordinates: 54675..54956 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A4D6P197
• Locus tag: E3395_RS23330
• Protein ID: WP_000084547.1
• Coordinates: 54409..54678 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3395_RS23295	49850..50416	+	567	WP_000493830.1	DUF2726 domain-containing protein	-
E3395_RS23300	50413..51144	+	732	WP_020833545.1	type-F conjugative transfer system pilin acetylase TraX	-
E3395_RS23305	51384..51854	+	471	Protein_56	phospholipase D family protein	-
E3395_RS23310	51998..52264	+	267	WP_001576653.1	replication regulatory protein RepA	-
E3395_RS23315	52514..52591	+	78	WP_001541552.1	RepA leader peptide Tap	-
E3395_RS23320	52572..53453	+	882	WP_023193063.1	incFII family plasmid replication initiator RepA	-
E3395_RS23330	54409..54678	+	270	WP_000084547.1	hypothetical protein	Antitoxin
E3395_RS23335	54675..54956	+	282	WP_000970006.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
E3395_RS23340	55108..55698	-	591	WP_031607984.1	plasmid pRiA4b ORF-3 family protein	-
E3395_RS23345	56944..57453	+	510	WP_131535394.1	hypothetical protein	-
E3395_RS23350	57762..58283	+	522	WP_136537703.1	hypothetical protein	-
E3395_RS23355	58280..58633	+	354	WP_157782941.1	helix-turn-helix transcriptional regulator	-
E3395_RS23360	58830..59531	+	702	WP_023251326.1	transcriptional activator SprB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..81940	81940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T124026 WP_000970006.1 NZ_CP039479:54675-54956 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T124026 NZ_CP039479:54675-54956 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 11553.68 Da
• Isoelectric Point: 12.7493

>AT124026 WP_000084547.1 NZ_CP039479:54409-54678 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Nucleotide

• Length: 270 bp

>AT124026 NZ_CP039479:54409-54678 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A4D6NZF1

Antitoxin

• AlphaFold DB: A0A4D6P197