Detailed information of TA system TA124023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 6625..7172
• Replicon: plasmid pCFSAN000968_1
• Accession: NZ_CP039474
• Organism: Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000968

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4D6NZF1
• Locus tag: E3396_RS23055
• Protein ID: WP_000970006.1
• Coordinates: 6625..6906 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A4D6P197
• Locus tag: E3396_RS23060
• Protein ID: WP_000084547.1
• Coordinates: 6903..7172 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3396_RS23030	2050..2751	-	702	WP_023251326.1	transcriptional activator SprB	-
E3396_RS23035	2948..3301	-	354	WP_157782941.1	helix-turn-helix transcriptional regulator	-
E3396_RS23040	3298..3819	-	522	WP_136537703.1	hypothetical protein	-
E3396_RS23045	4128..4637	-	510	WP_131535394.1	hypothetical protein	-
E3396_RS23050	5883..6473	+	591	WP_031607984.1	plasmid pRiA4b ORF-3 family protein	-
E3396_RS23055	6625..6906	-	282	WP_000970006.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
E3396_RS23060	6903..7172	-	270	WP_000084547.1	hypothetical protein	Antitoxin
E3396_RS23070	8128..9009	-	882	WP_023193063.1	incFII family plasmid replication initiator RepA	-
E3396_RS23075	8990..9067	-	78	WP_001541552.1	RepA leader peptide Tap	-
E3396_RS23080	9317..9583	-	267	WP_001576653.1	replication regulatory protein RepA	-
E3396_RS23085	9727..10197	-	471	Protein_12	phospholipase D family protein	-
E3396_RS23090	10437..11168	-	732	WP_020833545.1	type-F conjugative transfer system pilin acetylase TraX	-
E3396_RS23095	11165..11731	-	567	WP_000493830.1	DUF2726 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..81900	81900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (85-138)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T124023 WP_000970006.1 NZ_CP039474:c6906-6625 [Salmonella enterica subsp. enterica serovar Bareilly str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T124023 NZ_CP039474:c6906-6625 [Salmonella enterica subsp. enterica serovar Bareilly str.]
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Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT124023 WP_000084547.1 NZ_CP039474:c7172-6903 [Salmonella enterica subsp. enterica serovar Bareilly str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT124023 NZ_CP039474:c7172-6903 [Salmonella enterica subsp. enterica serovar Bareilly str.]
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Structures

Toxin

• AlphaFold DB: A0A4D6NZF1

Antitoxin

• AlphaFold DB: A0A4D6P197