Detailed information of TA system TA124019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 9882..10429
• Replicon: plasmid pCFSAN001112
• Accession: NZ_CP039470
• Organism: Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN001112

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4D6NZF1
• Locus tag: E3389_RS23075
• Protein ID: WP_000970006.1
• Coordinates: 10148..10429 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A4D6P197
• Locus tag: E3389_RS23070
• Protein ID: WP_000084547.1
• Coordinates: 9882..10151 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3389_RS23035	5323..5889	+	567	WP_000493830.1	DUF2726 domain-containing protein	-
E3389_RS23040	5886..6617	+	732	WP_020833545.1	type-F conjugative transfer system pilin acetylase TraX	-
E3389_RS23045	6857..7327	+	471	Protein_4	phospholipase D family protein	-
E3389_RS23050	7471..7737	+	267	WP_001576653.1	replication regulatory protein RepA	-
E3389_RS23055	7987..8064	+	78	WP_001541552.1	RepA leader peptide Tap	-
E3389_RS23060	8045..8926	+	882	WP_023193063.1	incFII family plasmid replication initiator RepA	-
E3389_RS23070	9882..10151	+	270	WP_000084547.1	hypothetical protein	Antitoxin
E3389_RS23075	10148..10429	+	282	WP_000970006.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
E3389_RS23080	10581..11171	-	591	WP_031607984.1	plasmid pRiA4b ORF-3 family protein	-
E3389_RS23085	12417..12926	+	510	WP_131535394.1	hypothetical protein	-
E3389_RS23090	13235..13756	+	522	WP_136537703.1	hypothetical protein	-
E3389_RS23095	13753..14106	+	354	WP_157782941.1	helix-turn-helix transcriptional regulator	-
E3389_RS23100	14303..15004	+	702	WP_023251326.1	transcriptional activator SprB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..81940	81940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-79)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T124019 WP_000970006.1 NZ_CP039470:10148-10429 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T124019 NZ_CP039470:10148-10429 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 11553.68 Da
• Isoelectric Point: 12.7493

>AT124019 WP_000084547.1 NZ_CP039470:9882-10151 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Nucleotide

• Length: 270 bp

>AT124019 NZ_CP039470:9882-10151 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A4D6NZF1

Antitoxin

• AlphaFold DB: A0A4D6P197