Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 43742..44267 Replicon plasmid pCFSAN001115
Accession NZ_CP039468
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN001115

Toxin (Protein)


Gene name ccdB Uniprot ID A0A4D6P1W7
Locus tag E3390_RS23215 Protein ID WP_020833585.1
Coordinates 43962..44267 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag E3390_RS23210 Protein ID WP_000813642.1
Coordinates 43742..43960 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3390_RS23190 39665..40717 + 1053 WP_020833588.1 Ig-like domain-containing protein -
E3390_RS23195 40916..41179 + 264 WP_136555995.1 hypothetical protein -
E3390_RS23200 41246..41764 + 519 WP_186266475.1 LuxR C-terminal-related transcriptional regulator -
E3390_RS23205 42551..42922 + 372 WP_100215268.1 DUF1311 domain-containing protein -
E3390_RS23210 43742..43960 + 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
E3390_RS23215 43962..44267 + 306 WP_020833585.1 type II toxin-antitoxin system toxin CcdB Toxin
E3390_RS23220 44576..45358 + 783 WP_020833584.1 site-specific integrase -
E3390_RS23225 45509..46450 - 942 WP_000728920.1 Rpn family recombination-promoting nuclease/putative transposase -
E3390_RS23230 47081..47335 + 255 WP_001749329.1 hypothetical protein -
E3390_RS23235 48024..49229 + 1206 WP_000427674.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81934 81934


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T124018 WP_020833585.1 NZ_CP039468:43962-44267 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T124018 NZ_CP039468:43962-44267 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT124018 WP_000813642.1 NZ_CP039468:43742-43960 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT124018 NZ_CP039468:43742-43960 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6P1W7

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References