Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 37415..37962 Replicon plasmid pCFSAN001140
Accession NZ_CP039464
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN001140

Toxin (Protein)


Gene name parE Uniprot ID A0A4D6NZF1
Locus tag E3388_RS23220 Protein ID WP_000970006.1
Coordinates 37681..37962 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4D6P197
Locus tag E3388_RS23215 Protein ID WP_000084547.1
Coordinates 37415..37684 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3388_RS23180 32856..33422 + 567 WP_000493830.1 DUF2726 domain-containing protein -
E3388_RS23185 33419..34150 + 732 WP_020833545.1 type-F conjugative transfer system pilin acetylase TraX -
E3388_RS23190 34390..34860 + 471 Protein_34 phospholipase D family protein -
E3388_RS23195 35004..35270 + 267 WP_001576653.1 replication regulatory protein RepA -
E3388_RS23200 35520..35597 + 78 WP_001541552.1 RepA leader peptide Tap -
E3388_RS23205 35578..36459 + 882 WP_023193063.1 incFII family plasmid replication initiator RepA -
E3388_RS23215 37415..37684 + 270 WP_000084547.1 hypothetical protein Antitoxin
E3388_RS23220 37681..37962 + 282 WP_000970006.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
E3388_RS23225 38114..38704 - 591 WP_031607984.1 plasmid pRiA4b ORF-3 family protein -
E3388_RS23230 39950..40459 + 510 WP_131535394.1 hypothetical protein -
E3388_RS23235 41222..41767 + 546 WP_077916522.1 helix-turn-helix transcriptional regulator -
E3388_RS23240 41964..42665 + 702 WP_023251326.1 transcriptional activator SprB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81940 81940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T124013 WP_000970006.1 NZ_CP039464:37681-37962 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T124013 NZ_CP039464:37681-37962 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT124013 WP_000084547.1 NZ_CP039464:37415-37684 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT124013 NZ_CP039464:37415-37684 [Salmonella enterica subsp. enterica serovar Bareilly str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6NZF1

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P197

References