Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1976349..1976832 Replicon chromosome
Accession NZ_CP039462
Organism Streptococcus suis strain WUSS351

Toxin (Protein)


Gene name relE Uniprot ID A0A4P7WQV5
Locus tag E8M06_RS09665 Protein ID WP_024391431.1
Coordinates 1976349..1976609 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4T2HAA1
Locus tag E8M06_RS09670 Protein ID WP_024391430.1
Coordinates 1976611..1976832 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M06_RS09640 1971635..1971847 - 213 WP_136581576.1 hypothetical protein -
E8M06_RS09645 1972041..1972673 - 633 WP_024410876.1 ABC transporter ATP-binding protein -
E8M06_RS09650 1972675..1974696 - 2022 WP_136581577.1 bacteriocin-associated integral membrane family protein -
E8M06_RS09655 1974758..1975048 - 291 WP_136581578.1 lactococcin 972 family bacteriocin -
E8M06_RS09660 1975412..1976272 + 861 WP_105120204.1 helix-turn-helix domain-containing protein -
E8M06_RS09665 1976349..1976609 - 261 WP_024391431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E8M06_RS09670 1976611..1976832 - 222 WP_024391430.1 translation repressor RelB Antitoxin
E8M06_RS09675 1977048..1977833 - 786 WP_024391429.1 Sua5/YciO/YrdC/YwlC family protein -
E8M06_RS09680 1977896..1978489 - 594 WP_136581579.1 3-isopropylmalate dehydratase small subunit -
E8M06_RS09685 1978489..1979880 - 1392 WP_136581580.1 3-isopropylmalate dehydratase large subunit -
E8M06_RS09690 1979877..1980929 - 1053 WP_136581581.1 3-isopropylmalate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10350.93 Da        Isoelectric Point: 9.8183

>T124011 WP_024391431.1 NZ_CP039462:c1976609-1976349 [Streptococcus suis]
MFHVEYSKKAQKQIRKLDKQIQRLLFAWVDKHLDGTVNPRLHGKGLTGDHANEWRYRIGDYRLICDIQDDRMVILALEFG
HRRDIY

Download         Length: 261 bp

>T124011 NZ_CP039462:c1976609-1976349 [Streptococcus suis]
ATGTTTCATGTAGAGTATTCTAAGAAGGCGCAGAAACAAATCAGAAAATTGGATAAGCAAATCCAAAGATTATTATTTGC
ATGGGTGGATAAACACTTAGACGGTACAGTTAATCCGAGGTTGCATGGCAAGGGATTGACAGGAGATCATGCCAATGAGT
GGCGTTATCGTATCGGTGATTATCGGCTGATTTGCGATATTCAGGATGATAGGATGGTTATTCTGGCACTTGAATTTGGT
CATCGTAGAGATATTTATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8596.58 Da        Isoelectric Point: 4.4915

>AT124011 WP_024391430.1 NZ_CP039462:c1976832-1976611 [Streptococcus suis]
MSTVTIRLNKEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLSIYHQAYEEYQKDPETISHADFKKELGL

Download         Length: 222 bp

>AT124011 NZ_CP039462:c1976832-1976611 [Streptococcus suis]
ATGAGTACAGTAACTATCCGATTAAACAAAGAGGAAGAAGTATTTTTCAAGAGCTATGCTCAATTGACTGGTCAAAGTCT
TTCAAGTTTATTTAAGAAGGCGCTTGAGCGTGATATTGAGGATGAGTATGATTTGAGCATTTACCATCAAGCCTACGAGG
AGTACCAGAAAGATCCTGAAACCATCAGTCATGCTGATTTCAAGAAGGAACTTGGTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7WQV5

Antitoxin

Source ID Structure
AlphaFold DB A0A4T2HAA1

References