Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1038593..1039088 Replicon chromosome
Accession NZ_CP039462
Organism Streptococcus suis strain WUSS351

Toxin (Protein)


Gene name relE Uniprot ID A0A116MST0
Locus tag E8M06_RS05165 Protein ID WP_024418294.1
Coordinates 1038593..1038859 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8F611
Locus tag E8M06_RS05170 Protein ID WP_024411326.1
Coordinates 1038849..1039088 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M06_RS05145 1034230..1035300 + 1071 WP_136581287.1 tyrosine recombinase XerS -
E8M06_RS05150 1035363..1036871 - 1509 WP_024401231.1 phosphoglucomutase -
E8M06_RS05155 1036948..1037889 - 942 WP_136581288.1 sensor histidine kinase -
E8M06_RS05160 1037886..1038554 - 669 WP_024413648.1 winged helix-turn-helix domain-containing protein -
E8M06_RS05165 1038593..1038859 - 267 WP_024418294.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E8M06_RS05170 1038849..1039088 - 240 WP_024411326.1 hypothetical protein Antitoxin
E8M06_RS05175 1039181..1041151 - 1971 WP_136581289.1 FtsX-like permease family protein -
E8M06_RS05180 1041152..1041904 - 753 WP_024400583.1 ABC transporter ATP-binding protein -
E8M06_RS05185 1042040..1042774 - 735 WP_011922410.1 ABC transporter permease -
E8M06_RS05190 1042776..1043522 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) - 907676..1084850 177174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10227.92 Da        Isoelectric Point: 10.4518

>T124009 WP_024418294.1 NZ_CP039462:c1038859-1038593 [Streptococcus suis]
MSYKVILSAKAQKQIRKLDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEVYK

Download         Length: 267 bp

>T124009 NZ_CP039462:c1038859-1038593 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCCGCTAAGGCTCAAAAGCAAATTCGAAAGTTGGATAAAACGGCTGCAAGTTTGATTTT
ACGGTATCTTTATAAGCATATTGACGGGTGTGACAACCCCAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAACTACAGGGTTATCGTCAGCATTGAGGATGATAAATTGATCGTAACAGCCCTAGAAGTC
GGGCATCGAAAAGAAGTATATAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT124009 WP_024411326.1 NZ_CP039462:c1039088-1038849 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT124009 NZ_CP039462:c1039088-1038849 [Streptococcus suis]
ATGGCAGCTATCACATTGAAAGTTTCTGAGCAGGACAAGCTTTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAATACGATGCGCGTGTGGCAGACCTTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGCATTGAGCCGATAACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A116MST0

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8F611

References