124007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 666489..667098 Replicon chromosome
Accession NZ_CP039457
Organism Streptococcus pasteurianus strain WUSP067

Toxin (Protein)


Gene name parE Uniprot ID E0PCM1
Locus tag E8M05_RS03620 Protein ID WP_000384814.1
Coordinates 666769..667098 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0PCM0
Locus tag E8M05_RS03615 Protein ID WP_000259348.1
Coordinates 666489..666779 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M05_RS03600 662305..662961 + 657 WP_003063985.1 response regulator transcription factor VncR -
E8M05_RS03605 662958..664280 + 1323 WP_003063986.1 sensor histidine kinase VncS -
E8M05_RS03610 665242..666159 + 918 Protein_634 IS30 family transposase -
E8M05_RS03615 666489..666779 + 291 WP_000259348.1 hypothetical protein Antitoxin
E8M05_RS03620 666769..667098 + 330 WP_000384814.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E8M05_RS03625 667401..667943 - 543 WP_000182451.1 hypothetical protein -
E8M05_RS03630 668116..669372 - 1257 WP_003063990.1 plasmid recombination protein -
E8M05_RS03635 669689..670123 - 435 WP_003063992.1 hypothetical protein -
E8M05_RS03640 670171..671034 - 864 WP_003063994.1 hypothetical protein -
E8M05_RS03650 671326..671967 - 642 WP_003063998.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12586.53 Da        Isoelectric Point: 8.3467

>T124007 WP_000384814.1 NZ_CP039457:666769-667098 [Streptococcus pasteurianus]
MDYKISYSAGALETLVEIKEYIINNFKSETSAKKVVDNIMQKISALEIFPEVGFDVDERFGKTLDKRHKTRGLTIGKDYI
ALYFVNDEKKEVVITHIVSTRSDYVKLFK

Download         Length: 330 bp

>T124007 NZ_CP039457:666769-667098 [Streptococcus pasteurianus]
TTGGATTATAAAATAAGTTATTCTGCTGGTGCATTGGAAACATTGGTAGAAATAAAAGAATATATAATTAATAATTTCAA
GTCAGAAACATCAGCGAAAAAAGTAGTTGATAATATTATGCAAAAAATAAGCGCTTTAGAGATTTTTCCTGAAGTAGGTT
TTGATGTTGATGAAAGATTTGGAAAAACTTTGGATAAACGTCATAAAACTAGAGGTTTAACAATTGGGAAAGATTATATA
GCTTTATATTTTGTTAATGATGAAAAAAAGGAAGTTGTCATTACCCATATTGTCTCAACTCGAAGCGATTATGTGAAATT
ATTCAAGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11037.64 Da        Isoelectric Point: 4.7463

>AT124007 WP_000259348.1 NZ_CP039457:666489-666779 [Streptococcus pasteurianus]
MVVAEKNRAVTFQANKELVSEAKEILNKKNLTLSHALRLFLQNVVVTNEIDLLSEEELEKEMLFKQLQTEIKQSIDDYEA
GVNTYSAEEVRKRLGL

Download         Length: 291 bp

>AT124007 NZ_CP039457:666489-666779 [Streptococcus pasteurianus]
ATGGTAGTTGCAGAAAAAAATAGAGCGGTCACTTTTCAAGCTAATAAAGAATTAGTAAGTGAAGCTAAAGAGATTTTAAA
TAAAAAGAATTTAACATTGTCACATGCTTTAAGATTATTTTTACAAAATGTTGTCGTTACTAATGAAATTGATTTATTGA
GCGAAGAAGAGCTGGAAAAAGAGATGTTATTTAAACAACTTCAAACAGAAATAAAGCAAAGTATTGATGATTATGAAGCT
GGTGTAAACACTTATTCAGCTGAAGAGGTGAGAAAACGTCTTGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A135YQK8

Antitoxin

Source ID Structure
AlphaFold DB A0A135YQS5

References