Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 680336..681900 Replicon chromosome
Accession NZ_CP039456
Organism Changchengzhania lutea strain SM1355

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag FAF07_RS03275 Protein ID WP_142783765.1
Coordinates 680336..681598 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag FAF07_RS03280 Protein ID WP_142783766.1
Coordinates 681598..681900 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAF07_RS03255 675347..676627 - 1281 WP_142783376.1 group II intron reverse transcriptase/maturase -
FAF07_RS03260 677321..677836 + 516 WP_142786525.1 hypothetical protein -
FAF07_RS03265 678120..679268 - 1149 WP_142783763.1 IS91 family transposase -
FAF07_RS03270 679268..680044 - 777 WP_142783764.1 tyrosine-type recombinase/integrase -
FAF07_RS03275 680336..681598 - 1263 WP_142783765.1 type II toxin-antitoxin system HipA family toxin Toxin
FAF07_RS03280 681598..681900 - 303 WP_142783766.1 helix-turn-helix domain-containing protein Antitoxin
FAF07_RS03285 682120..682527 - 408 WP_142783767.1 hypothetical protein -
FAF07_RS03290 682716..683972 - 1257 WP_142783768.1 site-specific integrase -
FAF07_RS03300 684432..686717 + 2286 WP_142786526.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(162-388)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-62)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 48039.96 Da        Isoelectric Point: 6.7676

>T124004 WP_142783765.1 NZ_CP039456:c681598-680336 [Changchengzhania lutea]
MGIEIFIWNIRVGALVKTPEGIAFEYDPEFVKTGLGLSPINLPLEGKRIYINEADWKETEGIPGLVYDSLPDKFGNDLLR
AYFMDKGLTENDIDVFAKLQYIGTRGMGALEFRPATEIKQTEDIISLEDIEKISMLSTQGKEALKTNVKDKNALLQILHI
GTSAGGARAKALIAINKENGTIKSGQLPLGQDYGYYLIKIDGANKTKLEEPSGYGKLEYAYSQMAKDCDIQMTECTLYKE
LHFLTKRFDRDDSGEKIHVHSLCGLLGLDYNKVGQYSYEHYFMAARRLNLGHDAIEEIYSRMVFNVLVHNCDDHTKNFSF
MMNQNGEWSLSPAFDLCYSYDNQNEWVNGHNMRINNKRTNISYEDLMVVGKKFNVKKRKAIFDKIKRVVDNFPEYGSKIK
VRQELIDQVEKNRPRIKQLI

Download         Length: 1263 bp

>T124004 NZ_CP039456:c681598-680336 [Changchengzhania lutea]
ATGGGAATAGAAATTTTTATTTGGAATATTAGAGTAGGTGCACTTGTTAAAACGCCTGAAGGAATTGCATTCGAATACGA
TCCTGAATTTGTAAAAACCGGTCTTGGTTTATCTCCAATAAACTTACCTCTAGAAGGTAAAAGGATTTACATTAATGAAG
CCGATTGGAAGGAAACAGAAGGCATTCCTGGACTCGTTTATGATTCATTACCAGACAAATTTGGTAACGATTTACTTCGT
GCTTACTTTATGGATAAAGGCCTTACAGAAAACGATATTGATGTATTTGCTAAACTTCAATACATAGGCACTAGAGGTAT
GGGAGCCTTAGAGTTTCGTCCGGCAACCGAAATCAAACAAACAGAAGACATTATTTCCTTAGAAGATATAGAGAAAATTT
CCATGCTAAGTACCCAAGGTAAAGAAGCGCTTAAAACCAATGTTAAAGATAAAAACGCACTATTACAGATATTACATATA
GGTACCTCTGCTGGTGGCGCCAGAGCAAAAGCATTAATAGCCATAAATAAAGAGAACGGAACTATTAAATCAGGACAATT
GCCCTTAGGTCAGGATTATGGATATTATTTAATTAAAATTGATGGAGCAAACAAAACGAAATTAGAAGAGCCAAGTGGTT
ATGGTAAGTTAGAATACGCCTATTCTCAAATGGCTAAAGATTGTGATATACAAATGACAGAATGTACGCTGTATAAAGAG
TTGCATTTTTTAACCAAGAGGTTTGATAGAGATGATAGTGGTGAAAAAATACATGTACATTCATTATGTGGTCTACTGGG
GCTAGATTACAATAAAGTTGGACAATATTCGTATGAGCATTATTTTATGGCAGCCAGAAGATTAAATTTAGGCCATGACG
CCATAGAAGAAATATACAGCAGAATGGTATTTAATGTACTGGTTCATAATTGTGATGACCATACCAAAAACTTTTCATTC
ATGATGAATCAAAATGGCGAATGGTCCTTAAGTCCGGCATTCGATTTGTGTTATTCATATGATAATCAAAATGAGTGGGT
GAATGGCCATAATATGCGTATAAATAATAAACGCACTAACATAAGCTATGAAGACCTAATGGTAGTTGGAAAAAAATTTA
ATGTTAAAAAACGAAAAGCCATTTTTGATAAAATAAAGCGAGTAGTGGATAATTTCCCGGAATATGGATCAAAAATTAAG
GTAAGGCAAGAACTGATAGATCAGGTTGAAAAAAATAGACCACGCATTAAGCAACTAATTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11430.48 Da        Isoelectric Point: 10.7322

>AT124004 WP_142783766.1 NZ_CP039456:c681900-681598 [Changchengzhania lutea]
MNYNILLNQDILEDLGKGLKQHRLNQNLTAKDLANKSGVSLRTITGFERGEKNISLLNLIEILRALRLLNNLESLFPKIP
VISPLELIELEKKKRKRASK

Download         Length: 303 bp

>AT124004 NZ_CP039456:c681900-681598 [Changchengzhania lutea]
ATGAATTATAATATATTATTAAATCAAGACATACTGGAAGACCTTGGTAAAGGCTTAAAACAACACCGTTTAAATCAAAA
CCTAACAGCTAAGGATTTAGCAAATAAAAGTGGTGTTAGCCTCAGAACGATAACAGGATTTGAACGTGGCGAAAAAAACA
TATCACTTTTAAATTTAATAGAGATACTTCGTGCATTAAGGCTATTAAACAACCTAGAGAGCTTATTTCCGAAAATACCA
GTAATAAGCCCACTAGAATTAATAGAATTAGAAAAGAAAAAACGCAAAAGAGCAAGTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References