Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 57808..58451 Replicon plasmid pSurvcare220
Accession NZ_CP039454
Organism Enterobacter bugandensis strain 220

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag FBF69_RS23455 Protein ID WP_023345587.1
Coordinates 57808..58224 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FBF69_RS23460 Protein ID WP_023345588.1
Coordinates 58221..58451 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF69_RS23440 53404..54039 + 636 WP_023345584.1 DUF1349 domain-containing protein -
FBF69_RS23445 54429..56303 + 1875 WP_048291888.1 beta-glucoside-specific PTS transporter subunit IIABC -
FBF69_RS23450 56313..57716 + 1404 WP_136486984.1 glycoside hydrolase family 1 protein -
FBF69_RS23455 57808..58224 - 417 WP_023345587.1 type II toxin-antitoxin system VapC family toxin Toxin
FBF69_RS23460 58221..58451 - 231 WP_023345588.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FBF69_RS23465 58869..59711 - 843 WP_048291887.1 nitroreductase family protein -
FBF69_RS23470 59779..60363 - 585 WP_023345591.1 TetR/AcrR family transcriptional regulator -
FBF69_RS23475 60475..60870 - 396 WP_023345592.1 helix-turn-helix transcriptional regulator -
FBF69_RS23480 60973..61818 + 846 WP_023345593.1 SDR family oxidoreductase -
FBF69_RS23485 61931..62359 + 429 WP_023345594.1 nuclear transport factor 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..151140 151140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15082.55 Da        Isoelectric Point: 7.8644

>T124002 WP_023345587.1 NZ_CP039454:c58224-57808 [Enterobacter bugandensis]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLMLEDWVN

Download         Length: 417 bp

>T124002 NZ_CP039454:c58224-57808 [Enterobacter bugandensis]
ATGAAGAAAACCTGGATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTACGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGATGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGCGGGAGTTTGAGCGGGTGCCGGGCCTGATGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT124002 WP_023345588.1 NZ_CP039454:c58451-58221 [Enterobacter bugandensis]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFAP

Download         Length: 231 bp

>AT124002 NZ_CP039454:c58451-58221 [Enterobacter bugandensis]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACATGGGGCTCGTTCGCGCAACTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGCGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References