Detailed information of TA system TA124001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4624189..4624705
• Replicon: chromosome
• Accession: NZ_CP039453
• Organism: Enterobacter bugandensis strain 220

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FBF69_RS22420
• Protein ID: WP_088204684.1
• Coordinates: 4624189..4624473 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8E1RL94
• Locus tag: FBF69_RS22425
• Protein ID: WP_023331889.1
• Coordinates: 4624463..4624705 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FBF69_RS22405	4620555..4621127	+	573	WP_049138570.1	PTS sugar transporter subunit IIA	-
FBF69_RS22410	4621497..4623635	+	2139	WP_048960133.1	anaerobic ribonucleoside-triphosphate reductase	-
FBF69_RS22415	4623721..4624185	+	465	WP_049138568.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
FBF69_RS22420	4624189..4624473	-	285	WP_088204684.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FBF69_RS22425	4624463..4624705	-	243	WP_023331889.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FBF69_RS22430	4624783..4626693	-	1911	WP_045259615.1	BglG family transcription antiterminator	-
FBF69_RS22435	4626713..4627849	-	1137	WP_063942969.1	lactonase family protein	-
FBF69_RS22440	4627875..4628615	-	741	WP_047367001.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10991.91 Da
• Isoelectric Point: 10.0526

>T124001 WP_088204684.1 NZ_CP039453:c4624473-4624189 [Enterobacter bugandensis]
MIYELEFDPRALKEWHKLGDTVKCQFKKKLADVLVNPRIESARLHGLSDCYKIKLRSLGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHEANKRL

Nucleotide

• Length: 285 bp

>T124001 NZ_CP039453:c4624473-4624189 [Enterobacter bugandensis]
ATGATTTATGAACTGGAGTTCGACCCGAGGGCTTTAAAGGAGTGGCATAAGCTGGGCGATACGGTGAAATGCCAGTTTAA
AAAGAAACTTGCTGACGTCTTAGTGAACCCCAGAATTGAATCGGCCCGCCTGCACGGCCTGTCGGATTGCTACAAAATAA
AACTCAGATCTCTGGGTTATCGTTTGGTTTATCAGGTTCAGGATAACGTAGTTACGGTATTTGTTATCGCTATCGGAAAG
AGAGAGAAATCAGCCGTTTATCATGAAGCAAATAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9030.41 Da
• Isoelectric Point: 4.7719

>AT124001 WP_023331889.1 NZ_CP039453:c4624705-4624463 [Enterobacter bugandensis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDELIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT124001 NZ_CP039453:c4624705-4624463 [Enterobacter bugandensis]
ATGGCCACGCTTAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCGTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCCGTGCGGTTACTGTTTCAGTACGTTGCGGAAACAGGGCGTATGCCGGTGAAAACTGTCACCATCAGTGACA
GTGAAGATGAACTGATACAGACAGTCCGGGAGCGACTGGCGAATCCACAAAAGGGAATTAAGGTTAGTCTGGATGATTTA
TGA