Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2120294..2120884 Replicon chromosome
Accession NZ_CP039453
Organism Enterobacter bugandensis strain 220

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag FBF69_RS10280 Protein ID WP_049138518.1
Coordinates 2120552..2120884 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A8E1V487
Locus tag FBF69_RS10275 Protein ID WP_041909206.1
Coordinates 2120294..2120551 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF69_RS10245 2115544..2116461 + 918 WP_028013742.1 nitrogen assimilation transcriptional regulator NAC -
FBF69_RS10250 2116558..2117508 + 951 WP_045260381.1 HTH-type transcriptional regulator Cbl -
FBF69_RS10255 2117557..2118477 - 921 WP_136485440.1 LysR family transcriptional regulator -
FBF69_RS10260 2118619..2119008 + 390 WP_136485442.1 RidA family protein -
FBF69_RS10265 2119057..2120016 + 960 WP_136485444.1 zinc-binding alcohol dehydrogenase family protein -
FBF69_RS10275 2120294..2120551 + 258 WP_041909206.1 antitoxin Antitoxin
FBF69_RS10280 2120552..2120884 + 333 WP_049138518.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FBF69_RS10290 2121178..2123367 - 2190 WP_028013734.1 TonB-dependent siderophore receptor -
FBF69_RS10295 2123394..2124719 - 1326 WP_088204839.1 SidA/IucD/PvdA family monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2110872..2120884 10012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11842.78 Da        Isoelectric Point: 10.2965

>T123989 WP_049138518.1 NZ_CP039453:2120552-2120884 [Enterobacter bugandensis]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTKTMGVIRCDQPRTI
DMAARNGMRLERIPDAVINEVLARLDAILS

Download         Length: 333 bp

>T123989 NZ_CP039453:2120552-2120884 [Enterobacter bugandensis]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTTCTCAT
CGTGTCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTAGTGGTTCCCGTCACCAGCGGCGGTAACTTTGCTCGCA
CGGCAGGTTTCACCGTTTCACTGGAAGGGGCGGGGACAAAAACGATGGGCGTTATTCGCTGCGACCAGCCCAGAACTATT
GATATGGCTGCCCGAAACGGCATGCGGCTGGAACGCATACCTGATGCTGTTATAAATGAAGTGCTTGCCAGGCTGGATGC
AATTCTGAGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9449.95 Da        Isoelectric Point: 4.6234

>AT123989 WP_041909206.1 NZ_CP039453:2120294-2120551 [Enterobacter bugandensis]
MYKTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT123989 NZ_CP039453:2120294-2120551 [Enterobacter bugandensis]
ATGTATAAAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGTTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAACAATGGCTGCCTGATCATTGAACCCCAAAAACGGCCTCATTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGTGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTA
GGAAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References