Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2232728..2233385 Replicon chromosome
Accession NZ_CP039452
Organism Enterobacter bugandensis strain 1367

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag FBF68_RS10870 Protein ID WP_028014322.1
Coordinates 2232975..2233385 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag FBF68_RS10865 Protein ID WP_010435322.1
Coordinates 2232728..2232994 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF68_RS10845 2228159..2229592 - 1434 WP_028014326.1 6-phospho-beta-glucosidase BglA -
FBF68_RS10850 2229709..2230440 - 732 WP_028014325.1 MurR/RpiR family transcriptional regulator -
FBF68_RS10855 2230706..2231365 + 660 WP_023331242.1 hemolysin III family protein -
FBF68_RS10860 2231453..2232433 - 981 WP_063155127.1 tRNA-modifying protein YgfZ -
FBF68_RS10865 2232728..2232994 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
FBF68_RS10870 2232975..2233385 + 411 WP_028014322.1 protein YgfX Toxin
FBF68_RS10875 2233392..2233913 - 522 WP_041908355.1 flavodoxin FldB -
FBF68_RS10880 2234015..2234911 + 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
FBF68_RS10885 2234940..2235653 + 714 WP_049136419.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FBF68_RS10890 2235659..2237392 + 1734 WP_063155126.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T123975 WP_028014322.1 NZ_CP039452:2232975-2233385 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T123975 NZ_CP039452:2232975-2233385 [Enterobacter bugandensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGGCTGGTTGCGGC
CATCGTTTTACTCATGCCGTGGCCGCTCAGCTATACGCCGCTGTGGCTGCTATTACTTTCGTTTGTTGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAACGCGCGTCAGGGCGAGATCAAGCTGCTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGTGTGCCCTGGATGCTTAACGCCGGGATGATGTTACGGTTACGCAAAGTGGGGGGCGGACGTTG
CCAGCACCTGTGGCTGGCGGCGGACAGTATGGACGCATCAGAATGGCGGGATCTGCGCCGGATGTTGCTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT123975 WP_010435322.1 NZ_CP039452:2232728-2232994 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT123975 NZ_CP039452:2232728-2232994 [Enterobacter bugandensis]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTACGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References