Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1221484..1222088 Replicon chromosome
Accession NZ_CP039452
Organism Enterobacter bugandensis strain 1367

Toxin (Protein)


Gene name hicA Uniprot ID A0A2T4Y605
Locus tag FBF68_RS05870 Protein ID WP_041911637.1
Coordinates 1221903..1222088 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822WYA1
Locus tag FBF68_RS05865 Protein ID WP_045630266.1
Coordinates 1221484..1221888 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF68_RS05850 1217036..1217854 - 819 WP_063155187.1 helix-turn-helix domain-containing protein -
FBF68_RS05855 1218080..1219480 + 1401 WP_028015059.1 MFS transporter -
FBF68_RS05860 1219491..1221440 + 1950 WP_063155188.1 glycoside hydrolase family 127 protein -
FBF68_RS05865 1221484..1221888 - 405 WP_045630266.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FBF68_RS05870 1221903..1222088 - 186 WP_041911637.1 type II toxin-antitoxin system HicA family toxin Toxin
FBF68_RS05875 1222298..1223038 - 741 WP_028015056.1 MipA/OmpV family protein -
FBF68_RS05880 1223156..1224121 + 966 WP_060572005.1 LysR family transcriptional regulator -
FBF68_RS05885 1224118..1225656 - 1539 WP_063155190.1 aldehyde dehydrogenase AldB -
FBF68_RS05890 1225822..1226706 + 885 WP_028015053.1 ROK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6852.04 Da        Isoelectric Point: 11.2341

>T123972 WP_041911637.1 NZ_CP039452:c1222088-1221903 [Enterobacter bugandensis]
VKSADVITVLIGHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T123972 NZ_CP039452:c1222088-1221903 [Enterobacter bugandensis]
GTGAAAAGTGCGGATGTCATTACCGTTCTGATCGGCCACGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCATCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCTAAGAAGGATATTAAACCGGGCACGCTCGCGCAGATAT
GGCGGCAGGCGGGAATTAAACACTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15046.81 Da        Isoelectric Point: 4.3282

>AT123972 WP_045630266.1 NZ_CP039452:c1221888-1221484 [Enterobacter bugandensis]
MFYPAYIHSDTDGSASGFFPDVPGCFFAGDSLDDAFQDAREALTAHFEALFEMDEALPLPGNVEVHLENHPDDFTGGQWL
LVDINMRQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT123972 NZ_CP039452:c1221888-1221484 [Enterobacter bugandensis]
ATGTTTTATCCGGCTTACATTCATTCTGACACCGACGGTAGCGCCAGCGGCTTTTTTCCTGACGTTCCAGGCTGTTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCACGTGAGGCGCTCACCGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTTCCGGGGAATGTCGAAGTGCACCTTGAAAATCACCCTGACGACTTCACGGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAGGCAGTTTGACGGCAGAGCCGAGCGTATCAACATCACGATGCCTCGACGTTTGCTGGTAAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTTGCTGAGGCAGCACGTCGCGTGCTGC
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4Y605

Antitoxin

Source ID Structure
AlphaFold DB A0A822WYA1

References