Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 850570..851047 Replicon chromosome
Accession NZ_CP039448
Organism Staphylococcus aureus strain VGC1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E8M03_RS04065 Protein ID WP_000052076.1
Coordinates 850570..850758 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E8M03_RS04070 Protein ID WP_001059690.1
Coordinates 850787..851047 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E8M03_RS04035 846608..847078 + 471 WP_000824462.1 hypothetical protein -
E8M03_RS04040 847419..848105 + 687 WP_001823812.1 thermonuclease family protein -
E8M03_RS04045 848462..848662 + 201 WP_001059082.1 cold-shock protein -
E8M03_RS04050 849161..849379 - 219 WP_000005888.1 hypothetical protein -
E8M03_RS04055 849441..849725 - 285 WP_001004397.1 hypothetical protein -
E8M03_RS04060 849813..850382 - 570 WP_001106657.1 hypothetical protein -
E8M03_RS04065 850570..850758 - 189 WP_000052076.1 hypothetical protein Toxin
E8M03_RS04070 850787..851047 - 261 WP_001059690.1 hypothetical protein Antitoxin
E8M03_RS04075 851388..851591 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
E8M03_RS04080 851588..851824 - 237 WP_000368687.1 hypothetical protein -
E8M03_RS04085 852049..852630 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
E8M03_RS04090 852703..853320 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
E8M03_RS04095 853476..853970 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
E8M03_RS04100 854369..854791 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
E8M03_RS04105 854939..855655 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 845250..934685 89435


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(28-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T123959 WP_000052076.1 NZ_CP039448:c850758-850570 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T123959 NZ_CP039448:c850758-850570 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT123959 WP_001059690.1 NZ_CP039448:c851047-850787 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT123959 NZ_CP039448:c851047-850787 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References