Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 197067..197657 Replicon plasmid pCFSAN086833
Accession NZ_CP039446
Organism Salmonella enterica subsp. enterica serovar Infantis strain VNSEC001

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag E5158_RS23805 Protein ID WP_023994178.1
Coordinates 197067..197399 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag E5158_RS23810 Protein ID WP_023994179.1
Coordinates 197400..197657 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5158_RS23795 193341..195563 + 2223 WP_023994175.1 DEAD/DEAH box helicase -
E5158_RS23800 195862..196467 - 606 Protein_189 IS481 family transposase -
E5158_RS23805 197067..197399 - 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
E5158_RS23810 197400..197657 - 258 WP_023994179.1 hypothetical protein Antitoxin
E5158_RS23815 198268..201123 + 2856 Protein_192 hypothetical protein -
E5158_RS23820 201133..202158 - 1026 WP_023994180.1 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..321890 321890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 16354.62 Da        Isoelectric Point: 5.5500

>T123957 WP_023994178.1 NZ_CP039446:c197399-197067 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 333 bp

>T123957 NZ_CP039446:c197399-197067 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 12675.20 Da        Isoelectric Point: 5.5500

>AT123957 WP_023994179.1 NZ_CP039446:c197657-197400 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFF

Download         Length: 258 bp

>AT123957 NZ_CP039446:c197657-197400 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References