Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 182820..183577 Replicon plasmid pCFSAN086833
Accession NZ_CP039446
Organism Salmonella enterica subsp. enterica serovar Infantis strain VNSEC001

Toxin (Protein)


Gene name tacT Uniprot ID A0A241PXX4
Locus tag E5158_RS23720 Protein ID WP_023994162.1
Coordinates 182820..183302 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A727Z1I8
Locus tag E5158_RS23725 Protein ID WP_001195098.1
Coordinates 183293..183577 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5158_RS23680 178092..178343 + 252 WP_023994153.1 helix-turn-helix domain-containing protein -
E5158_RS23685 178385..178612 - 228 WP_072205048.1 hypothetical protein -
E5158_RS23690 178656..179612 - 957 WP_023994155.1 Rpn family recombination-promoting nuclease/putative transposase -
E5158_RS23695 179683..179925 - 243 WP_023994156.1 hypothetical protein -
E5158_RS23700 179927..180900 - 974 Protein_169 IS256 family transposase -
E5158_RS23705 181127..181479 + 353 Protein_170 transposase -
E5158_RS23710 181553..181762 - 210 WP_023994160.1 hemolysin expression modulator Hha -
E5158_RS23715 182079..182505 - 427 Protein_172 transposase -
E5158_RS23720 182820..183302 - 483 WP_023994162.1 GNAT family N-acetyltransferase Toxin
E5158_RS23725 183293..183577 - 285 WP_001195098.1 DUF1778 domain-containing protein Antitoxin
E5158_RS23730 183748..183822 - 75 Protein_175 helix-turn-helix domain-containing protein -
E5158_RS23735 183865..184143 + 279 WP_023994163.1 PIN domain-containing protein -
E5158_RS23740 184365..184700 - 336 WP_023994164.1 hypothetical protein -
E5158_RS23745 184726..185152 - 427 Protein_178 DUF977 family protein -
E5158_RS23750 185739..186044 - 306 WP_023994167.1 type II toxin-antitoxin system RelE/ParE family toxin -
E5158_RS23755 186041..186328 - 288 WP_031619580.1 damage-inducible protein J -
E5158_RS23760 186297..187141 - 845 Protein_181 site-specific tyrosine recombinase XerC -
E5158_RS23765 187274..187603 + 330 WP_023994169.1 IS66 family insertion sequence hypothetical protein -
E5158_RS23770 187590..187757 + 168 WP_023994170.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..321890 321890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 23713.45 Da        Isoelectric Point: 5.5500

>T123956 WP_023994162.1 NZ_CP039446:c183302-182820 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
F

Download         Length: 483 bp

>T123956 NZ_CP039446:c183302-182820 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 13999.79 Da        Isoelectric Point: 5.5500

>AT123956 WP_001195098.1 NZ_CP039446:c183577-183293 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFF

Download         Length: 285 bp

>AT123956 NZ_CP039446:c183577-183293 [Salmonella enterica subsp. enterica serovar Infantis]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXX4

Antitoxin

Source ID Structure
AlphaFold DB A0A727Z1I8

References