Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 162915..163558 Replicon plasmid pCFSAN086833
Accession NZ_CP039446
Organism Salmonella enterica subsp. enterica serovar Infantis strain VNSEC001

Toxin (Protein)


Gene name vagD Uniprot ID A0A5T8FJ24
Locus tag E5158_RS23595 Protein ID WP_023994137.1
Coordinates 163142..163558 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5T3Q059
Locus tag E5158_RS23590 Protein ID WP_023994136.1
Coordinates 162915..163145 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5158_RS23555 158492..159028 - 537 WP_023994130.1 fimbrial protein -
E5158_RS23560 160310..161025 + 716 Protein_141 transposase -
E5158_RS23565 161015..161101 - 87 Protein_142 cytoplasmic protein -
E5158_RS23570 161127..161477 - 351 Protein_143 3'-5' exonuclease -
E5158_RS23575 161474..161764 - 291 WP_023994133.1 hypothetical protein -
E5158_RS23580 161766..162071 - 306 WP_023994134.1 type II toxin-antitoxin system toxin CcdB -
E5158_RS23585 162073..162291 - 219 WP_023994135.1 type II toxin-antitoxin system antitoxin CcdA -
E5158_RS23590 162915..163145 + 231 WP_023994136.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E5158_RS23595 163142..163558 + 417 WP_023994137.1 type II toxin-antitoxin system VapC family toxin Toxin
E5158_RS23600 164128..164976 - 849 WP_023994138.1 SdiA-regulated domain-containing protein -
E5158_RS23605 165002..165163 - 162 WP_001816720.1 hypothetical protein -
E5158_RS23610 165424..165636 - 213 WP_023994139.1 PefI -
E5158_RS23615 165702..166292 - 591 WP_023994140.1 hypothetical protein -
E5158_RS23620 166495..167259 - 765 WP_023994141.1 minor fimbrial protein -
E5158_RS23625 167287..168078 - 792 WP_023994142.1 F4 (K88) fimbria minor subunit FaeH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..321890 321890


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 17834.22 Da        Isoelectric Point: 12.9398

>T123955 WP_023994137.1 NZ_CP039446:163142-163558 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 417 bp

>T123955 NZ_CP039446:163142-163558 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT123955 WP_023994136.1 NZ_CP039446:162915-163145 [Salmonella enterica subsp. enterica serovar Infantis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT123955 NZ_CP039446:162915-163145 [Salmonella enterica subsp. enterica serovar Infantis]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FJ24

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q059

References