Detailed information of TA system TA123954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 161766..162291
• Replicon: plasmid pCFSAN086833
• Accession: NZ_CP039446
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain VNSEC001

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A5Y5FBU7
• Locus tag: E5158_RS23580
• Protein ID: WP_023994134.1
• Coordinates: 161766..162071 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A5T8X4Y4
• Locus tag: E5158_RS23585
• Protein ID: WP_023994135.1
• Coordinates: 162073..162291 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5158_RS23550	157708..158439	-	732	WP_023994129.1	fimbria/pilus periplasmic chaperone	-
E5158_RS23555	158492..159028	-	537	WP_023994130.1	fimbrial protein	-
E5158_RS23560	160310..161025	+	716	Protein_141	transposase	-
E5158_RS23565	161015..161101	-	87	Protein_142	cytoplasmic protein	-
E5158_RS23570	161127..161477	-	351	Protein_143	3'-5' exonuclease	-
E5158_RS23575	161474..161764	-	291	WP_023994133.1	hypothetical protein	-
E5158_RS23580	161766..162071	-	306	WP_023994134.1	type II toxin-antitoxin system toxin CcdB	Toxin
E5158_RS23585	162073..162291	-	219	WP_023994135.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
E5158_RS23590	162915..163145	+	231	WP_023994136.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
E5158_RS23595	163142..163558	+	417	WP_023994137.1	type II toxin-antitoxin system VapC family toxin	-
E5158_RS23600	164128..164976	-	849	WP_023994138.1	SdiA-regulated domain-containing protein	-
E5158_RS23605	165002..165163	-	162	WP_001816720.1	hypothetical protein	-
E5158_RS23610	165424..165636	-	213	WP_023994139.1	PefI	-
E5158_RS23615	165702..166292	-	591	WP_023994140.1	hypothetical protein	-
E5158_RS23620	166495..167259	-	765	WP_023994141.1	minor fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..321890	321890

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T123954 WP_023994134.1 NZ_CP039446:c162071-161766 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T123954 NZ_CP039446:c162071-161766 [Salmonella enterica subsp. enterica serovar Infantis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT123954 WP_023994135.1 NZ_CP039446:c162291-162073 [Salmonella enterica subsp. enterica serovar Infantis]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT123954 NZ_CP039446:c162291-162073 [Salmonella enterica subsp. enterica serovar Infantis]
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A5Y5FBU7

Antitoxin

• AlphaFold DB: A0A5T8X4Y4